Discontinued Product

Z-IETD-FMK (Cat. No. 2170) has been withdrawn from sale for commercial reasons.
Description: Caspase-8 inhibitor
Chemical Name: Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
Literature (6)

Biological Activity for Z-IETD-FMK

Inhibitor of caspase-8. Blocks TNFα-induced cytochrome c release and apoptosis in human leukemic U937 cells. Also inhibits nuclear protein cleavage in Jurkat, MCF-7 and HeLa cells in vitro.

Technical Data for Z-IETD-FMK

M. Wt 654.69
Formula C30H43FN4O11
Sequence Z-IE(OMe)-TD(OMe)-fluoromethylketone
Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Z-IETD-FMK

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for Z-IETD-FMK

References are publications that support the biological activity of the product.

Taimen and Kallajoki (2003) NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J.Cell Sci. 116 571 PMID: 12508117

Bang et al (2004) Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659 PMID: 15276073

Partheniou et al (2001) c-IAP1 blocks TNFα-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells. Biochem.Biophys.Res.Comm. 287 181

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Keywords: Z-IETD-FMK, Z-IETD-FMK supplier, Caspases, 2170, Tocris Bioscience

Citations for Z-IETD-FMK

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