Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
(Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 13.71 mg/ml in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 685.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.46 mL||7.29 mL||14.58 mL|
|5 mM||0.29 mL||1.46 mL||2.92 mL|
|10 mM||0.15 mL||0.73 mL||1.46 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the biological activity of the product.
Izban et al (2001) Characterization of NF-κB expression in Hodgkin's disease: inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells. Mod.Pathol. 14 297 PMID: 11301346
Bang et al (2004) Differential response to MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659 PMID: 15276073
Chou et al (2004) Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death. Biochem.J. 383 63 PMID: 15198639
If you know of a relevant reference for Z-DQMD-FMK, please let us know.
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Keywords: Z-DQMD-FMK, Z-DQMD-FMK supplier, Caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2168, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.