Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
(Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 13.71 mg/ml in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 685.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.46 mL||7.29 mL||14.58 mL|
|5 mM||0.29 mL||1.46 mL||2.92 mL|
|10 mM||0.15 mL||0.73 mL||1.46 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Izban et al (2001) Characterization of NF-κB expression in Hodgkin's disease: inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells. Mod.Pathol. 14 297 PMID: 11301346
Bang et al (2004) Differential response to MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659 PMID: 15276073
Chou et al (2004) Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death. Biochem.J. 383 63 PMID: 15198639
If you know of a relevant reference for Z-DQMD-FMK, please let us know.
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Keywords: Z-DQMD-FMK, supplier, Caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, Caspases, Caspases, Tocris Bioscience
Citations for Z-DQMD-FMK
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