Z-DQMD-FMK

Discontinued Product

Z-DQMD-FMK (Cat. No. 2168) has been withdrawn from sale for commercial reasons.
Cat.No. 2168 - Z-DQMD-FMK | Z-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Description: Caspase-3 inhibitor
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity

Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.

Technical Data

M. Wt 685.72
Formula C29H40FN5O11S
Sequence DQMD

(Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone)

Storage Desiccate at -20°C
PubChem ID 644197
InChI Key QFITYVNVMNJELE-TUFLPTIASA-N
Smiles [H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: Z-DQMD-FMK, Z-DQMD-FMK supplier, Caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2168, Tocris Bioscience

1 Citation for Z-DQMD-FMK

Citations are publications that use Tocris products. Selected citations for Z-DQMD-FMK include:

Allam et al (2018) HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. PLoS One 13 e0194185 PMID: 29601578


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Huntington's Disease

Huntington's Disease Poster

Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.