Z-Cyclopentyl-AP4

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Cat.No. 3249 - Z-Cyclopentyl-AP4 | C6H12NO5P | CAS No. 103439-17-4
Description: Group III mGlu agonist (mGlu4 > mGlu8 > mGlu7)
Chemical Name: cis-(±)-1-Amino-3-phosphonocyclopentane carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. Selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4 (Cat No. 0103).

Technical Data

M. Wt 209.14
Formula C6H12NO5P
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 103439-17-4
PubChem ID 56972223
InChI Key GLBQBTFFQHNHGC-RPBIHNRISA-N
Smiles [H][C@@]1(CC[C@@](N)(C1)C(O)=O)P(O)(O)=O.[H][C@]1(CC[C@](N)(C1)C(O)=O)P(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 10.46 50

Preparing Stock Solutions

The following data is based on the product molecular weight 209.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.78 mL 23.91 mL 47.81 mL
5 mM 0.96 mL 4.78 mL 9.56 mL
10 mM 0.48 mL 2.39 mL 4.78 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Crooks et al (1986) Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J.Med.Chem. 29 1988 PMID: 3020251

Ayala et al (2008) Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. Neuropharmacology 54 804 PMID: 18255102

Jones et al (2008) Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synpase. Neuropharmacology 55 440 PMID: 18625254


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Citations for Z-Cyclopentyl-AP4

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