You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Y 39983 dihydrochloride
Discontinued ProductY 39983 dihydrochloride (Cat. No. 3846) has been withdrawn from sale for commercial reasons.
Selective Rho-kinase inhibitor (IC50 values are 0.0036, 0.42 and 0.81 μM for ROCK, PKC and CaMKII respectively). Promotes neurite regeneration in vitro and induces axonal regeneration in vivo. Derived from Y-27632 (Cat. No. 1254).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Sagawa et al (2007) A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp.Neurol. 205 230 PMID: 17359977
Tokushige et al (2007) Effects of topical administratino of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest.Opthalmol.Vis.Sci. 48 3216
View Related Products by Target
View Related Products by Product Action
Keywords: Y 39983 dihydrochloride, Y 39983 dihydrochloride supplier, Y39983, dihydrochloride, stem, cells, rho-kinase, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROCK, ROK, inhibitors, inhibits, Rho-kinases, Stem, Cell, Signaling, 3846, Tocris Bioscience
Citations for Y 39983 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Y 39983 dihydrochloride.
Reviews for Y 39983 dihydrochloride
There are currently no reviews for this product. Be the first to review Y 39983 dihydrochloride and earn rewards!
Have you used Y 39983 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.