Y 39983 dihydrochloride

Discontinued Product

Unfortunately Y 39983 dihydrochloride (Cat. No. 3846) has been withdrawn from sale for commercial reasons.
Cat.No. 3846 - Y 39983 dihydrochloride | C16H16N4O.2HCl | CAS No. 203911-26-6
Description: Selective Rho-kinase (ROCK) inhibitor
Chemical Name: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective Rho-kinase inhibitor (IC50 values are 0.0036, 0.42 and 0.81 μM for ROCK, PKC and CaMKII respectively). Promotes neurite regeneration in vitro and induces axonal regeneration in vivo. Derived from Y-27632 (Cat. No. 1254).

Technical Data

M. Wt 353.25
Formula C16H16N4O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 203911-26-6
Smiles C[C@@H](N)C1=CC=C(C(NC2=C(C=CN3)C3=NC=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 353.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.31 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Sagawa et al (2007) A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp.Neurol. 205 230 PMID: 17359977

Tokushige et al (2007) Effects of topical administratino of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest.Opthalmol.Vis.Sci. 48 3216 PMID:

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Citations for Y 39983 dihydrochloride

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