Y 39983 dihydrochloride

Discontinued Product

Y 39983 dihydrochloride (Cat. No. 3846) has been withdrawn from sale for commercial reasons.
Cat.No. 3846 - Y 39983 dihydrochloride | C16H16N4O.2HCl | CAS No. 203911-26-6
Description: Selective Rho-kinase (ROCK) inhibitor
Chemical Name: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective Rho-kinase inhibitor (IC50 values are 0.0036, 0.42 and 0.81 μM for ROCK, PKC and CaMKII respectively). Promotes neurite regeneration in vitro and induces axonal regeneration in vivo. Derived from Y-27632 (Cat. No. 1254).

Technical Data

M. Wt 353.25
Formula C16H16N4O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 203911-26-6
Smiles C[C@@H](N)C1=CC=C(C(NC2=C(C=CN3)C3=NC=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Sagawa et al (2007) A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp.Neurol. 205 230 PMID: 17359977

Tokushige et al (2007) Effects of topical administratino of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest.Opthalmol.Vis.Sci. 48 3216

View Related Products by Product Action

View all Rho-Kinases Inhibitors

Keywords: Y 39983 dihydrochloride, Y 39983 dihydrochloride supplier, Y39983, dihydrochloride, stem, cells, rho-kinase, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROCK, ROK, inhibitors, inhibits, Rho-kinases, Stem, Cell, Signaling, 3846, Tocris Bioscience

Citations for Y 39983 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Y 39983 dihydrochloride.

Reviews for Y 39983 dihydrochloride

There are currently no reviews for this product. Be the first to review Y 39983 dihydrochloride and earn rewards!

Have you used Y 39983 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases