Y 39983 dihydrochloride

Discontinued Product

Y 39983 dihydrochloride (Cat. No. 3846) has been withdrawn from sale for commercial reasons.
Description: Selective Rho-kinase (ROCK) inhibitor
Chemical Name: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide dihydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for Y 39983 dihydrochloride

Selective Rho-kinase inhibitor (IC50 values are 0.0036, 0.42 and 0.81 μM for ROCK, PKC and CaMKII respectively). Promotes neurite regeneration in vitro and induces axonal regeneration in vivo. Derived from Y-27632 (Cat. No. 1254).

Technical Data for Y 39983 dihydrochloride

M. Wt 353.25
Formula C16H16N4O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 203911-26-6
Smiles C[C@@H](N)C1=CC=C(C(NC2=C(C=CN3)C3=NC=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Y 39983 dihydrochloride

References for Y 39983 dihydrochloride

References are publications that support the biological activity of the product.

Sagawa et al (2007) A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp.Neurol. 205 230 PMID: 17359977

Tokushige et al (2007) Effects of topical administratino of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest.Opthalmol.Vis.Sci. 48 3216

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Citations for Y 39983 dihydrochloride

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Currently there are no citations for Y 39983 dihydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.