Y-27152

Discontinued Product

Y-27152 (Cat. No. 2077) has been withdrawn from sale for commercial reasons.
Cat.No. 2077 - Y-27152 | C21H22N2O4 | CAS No. 127408-30-4
Description: Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Technical Data

M. Wt 366.41
Formula C21H22N2O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 127408-30-4
PubChem ID 6918184
InChI Key RHFUXPCCELGMFC-UXHICEINSA-N
Smiles CC(=O)N(OCC1=CC=CC=C1)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197 PMID: 9128839

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Keywords: Y-27152, Y-27152 supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Potassium, Channels, 2077, Tocris Bioscience

Citations for Y-27152

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Currently there are no citations for Y-27152.

Reviews for Y-27152

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Product was used on Kir2.2 channels to understand channel modulation.
By Anonymous on 11/29/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

Y-27152 ws used on Kir2.2 channels expressed on human brain cells to understand channel modulation at increasing concentrations.

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Literature in this Area

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