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Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||1.83||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.92 mL||54.58 mL||109.17 mL|
|1.25 mM||2.18 mL||10.92 mL||21.83 mL|
|2.5 mM||1.09 mL||5.46 mL||10.92 mL|
|12.5 mM||0.22 mL||1.09 mL||2.18 mL|
References are publications that support the biological activity of the product.
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381
Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197 PMID: 9128839
If you know of a relevant reference for Y-27152, please let us know.
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Keywords: Y-27152, Y-27152 supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Potassium, Channels, 2077, Tocris Bioscience
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Reviews for Y-27152
Average Rating: 5 (Based on 1 Review.)
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