Y-27152

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Cat.No. 2077 - Y-27152 | C21H22N2O4 | CAS No. 127408-30-4
Description: Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Technical Data

M. Wt 366.41
Formula C21H22N2O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 127408-30-4
PubChem ID 6918184
InChI Key RHFUXPCCELGMFC-UXHICEINSA-N
Smiles CC(=O)N(OCC1=CC=CC=C1)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.83 5 with gentle warming
DMSO 9.16 25

Preparing Stock Solutions

The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.92 mL 54.58 mL 109.17 mL
1.25 mM 2.18 mL 10.92 mL 21.83 mL
2.5 mM 1.09 mL 5.46 mL 10.92 mL
12.5 mM 0.22 mL 1.09 mL 2.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197 PMID: 9128839


If you know of a relevant reference for Y-27152, please let us know.

View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Activators

Keywords: Y-27152, Y-27152 supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Potassium, Channels, 2077, Tocris Bioscience

Citations for Y-27152

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Currently there are no citations for Y-27152. Do you know of a great paper that uses Y-27152 from Tocris? Please let us know.

Reviews for Y-27152

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Product was used on Kir2.2 channels to understand channel modulation.
By Anonymous on 11/29/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

Y-27152 ws used on Kir2.2 channels expressed on human brain cells to understand channel modulation at increasing concentrations.

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Literature in this Area

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