Y-26763

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Cat.No. 2076 - Y-26763 | C14H16N2O4 | CAS No. 127408-31-5
Description: Kir6 (KATP) channel opener
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Technical Data

M. Wt 276.29
Formula C14H16N2O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 127408-31-5
PubChem ID 121878
InChI Key IWTCFIIOUXJOOV-OLZOCXBDSA-N
Smiles CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 27.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.19 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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References

References are publications that support the biological activity of the product.

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730 PMID: 1578381

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels Eur.J.Pharmacol. 323 197 PMID: 9128839

Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of Ins release from human pancreatic β-cells Eur.J.Pharmacol. 486 133 PMID: 14975702


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View Related Products by Product Action

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Keywords: Y-26763, Y-26763 supplier, KATP, channel, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, rectifier, Channels, 2076, Tocris Bioscience

Citations for Y-26763

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Reviews for Y-26763

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Y-26763 was used to Kir2 channels to understand channel opening..
By Anonymous on 11/29/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.

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Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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