Xanthurenic acid

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Cat.No. 4120 - Xanthurenic acid | C10H7NO4 | CAS No. 59-00-7
Description: Selectively activates group II mGlu receptors
Chemical Name: 4,8-Dihydroxyquinoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Shown to selectively activate group II mGlu receptors in transfected HEK293 cells at nanomolar concentrations. Attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors.

Technical Data

M. Wt 205.17
Formula C10H7NO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 59-00-7
PubChem ID 5699
InChI Key FBZONXHGGPHHIY-UHFFFAOYSA-N
Smiles OC1=C2C(C(O)=CC(C(O)=O)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 205.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.87 mL 24.37 mL 48.74 mL
5 mM 0.97 mL 4.87 mL 9.75 mL
10 mM 0.49 mL 2.44 mL 4.87 mL
50 mM 0.1 mL 0.49 mL 0.97 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Han et al (2007) The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis. J.Insect.Physiol. 53 254 PMID: 17070835

Mauro et al (2010) Xanthurenic acid, a novel endogenous ligand for metabotropic glutamate receptors. Program No. 643.1/F2. 2010 Neuroscience Meeting Pl 2010 (Online) PMID:


If you know of a relevant reference for Xanthurenic acid, please let us know.

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Keywords: metabotropic glutamate receptors mGlu ligands group II 2 mglu2 mglu3 Glutamate (Metabotropic) Group II Receptors

Citations for Xanthurenic acid

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Pathways for Xanthurenic acid

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