WWL 123

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Description: α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic
Chemical Name: N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
Purity: ≥98% (HPLC)

Biological Activity for WWL 123

WWL 123 is an α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB1 and CB2 receptors, but is GABAA receptor dependent. Brain penetrant.

Other Information for WWL 123

There appears to be some confusion about the structure of WWL 123. Tocris sells N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester [1338574-83-6], which has been confirmed by the inventor, Prof B. Cravatt, as the correct compound. Other vendors sell the corresponding 3-yl regioisomer [1338575-41-9], which is the incorrect compound.

Compound Libraries for WWL 123

WWL 123 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WWL 123

M. Wt 436.5
Formula C28H24N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1338574-83-6
PubChem ID 90209976
Smiles NC(C1=CC=C(C2=CC=C(OC(N(C)CC3=CC(C4=CC=CC=C4)=CC=C3)=O)C=C2)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WWL 123

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.65 100

Preparing Stock Solutions for WWL 123

The following data is based on the product molecular weight 436.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.45 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for WWL 123

References are publications that support the biological activity of the product.

Naydenov et al (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83 361 PMID: 25033180

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Citations for WWL 123

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