Cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.73 mL||23.66 mL||47.32 mL|
|5 mM||0.95 mL||4.73 mL||9.46 mL|
|10 mM||0.47 mL||2.37 mL||4.73 mL|
|50 mM||0.09 mL||0.47 mL||0.95 mL|
References are publications that support the biological activity of the product.
Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737 PMID: 14757700
Bodding (2007) TRP proteins and cancer. Cell Signal. 19 617 PMID: 17029734
Rovner (2007) Better than mint. C&EN 85 95
If you know of a relevant reference for WS 3, please let us know.
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Keywords: WS 3, WS 3 supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS3, TRPM, 2927, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.