WS 3

Pricing Availability Delivery Time Qty
Cat.No. 2927 - WS 3 | C13H25NO | CAS No. 39711-79-0
Description: TRPM8 agonist; cooling agent
Chemical Name: N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
Purity: ≥99% (HPLC)

Biological Activity

Cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM).

Technical Data

M. Wt 211.34
Formula C13H25NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 39711-79-0
PubChem ID 62907
Smiles CC1CC(C(NCC)=O)C(C(C)C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.13 100
ethanol 21.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 211.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.66 mL 47.32 mL
5 mM 0.95 mL 4.73 mL 9.46 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737 PMID: 14757700

Bodding (2007) TRP proteins and cancer. Cell Signal. 19 617 PMID: 17029734

Rovner (2007) Better than mint. C&EN 85 95 PMID:

If you know of a relevant reference for WS 3, please let us know.

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Citations for WS 3

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