WS 3

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Cat.No. 2927 - WS 3 | C13H25NO | CAS No. 39711-79-0
Description: TRPM8 agonist; cooling agent
Chemical Name: N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM).

Technical Data

M. Wt 211.34
Formula C13H25NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 39711-79-0
PubChem ID 62907
InChI Key VUNOFAIHSALQQH-UHFFFAOYSA-N
Smiles CC1CC(C(NCC)=O)C(C(C)C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.13 100
ethanol 21.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 211.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.66 mL 47.32 mL
5 mM 0.95 mL 4.73 mL 9.46 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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References

References are publications that support the biological activity of the product.

Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737 PMID: 14757700

Bodding (2007) TRP proteins and cancer. Cell Signal. 19 617 PMID: 17029734

Rovner (2007) Better than mint. C&EN 85 95


If you know of a relevant reference for WS 3, please let us know.

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Keywords: WS 3, WS 3 supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS3, TRPM, 2927, Tocris Bioscience

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