VU 1545

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Cat.No. 3325 - VU 1545 | C22H15FN4O3 | CAS No. 890764-63-3
Description: mGlu5 positive allosteric modulator
Chemical Name: N-[1-(2-Fluorophenyl)-3-phenyl-1H-pyrazol-5-yl]-4-nitrobenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (EC50 = 9.6 nM, Ki = 156 nM at rat mGlu5).

Compound Libraries

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Technical Data

M. Wt 402.38
Formula C22H15FN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 890764-63-3
PubChem ID 11625520
InChI Key BRAZLURTFMCAHU-UHFFFAOYSA-N
Smiles O=C(C4=CC=C([N+]([O-])=O)C=C4)NC1=CC(C3=CC=CC=C3)=NN1C2=CC=CC=C2F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 402.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.43 mL 24.85 mL
5 mM 0.5 mL 2.49 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

de Paulis et al (2006) Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J.Med.Chem. 49 3332 PMID: 16722652


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Citations for VU 1545

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