Vilazodone hydrochloride

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Description: Potent 5-HT1A partial agonist and SSRI; antidepressant
Alternative Names: EMD 68843,SB 659746A
Chemical Name: 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for Vilazodone hydrochloride

Vilazodone hydrochloride is a potent 5-HT1A partial agonist and serotonin-selective reuptake inhibitor (SSRI) (IC50 values are 0.2 and 0.5 nM respectively). Antidepressant.

Compound Libraries for Vilazodone hydrochloride

Vilazodone hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Vilazodone hydrochloride

M. Wt 477.99
Formula C26H27N5O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 163521-08-2
PubChem ID 6918313
Smiles NC(C1=CC2=C(C=CC(N3CCN(CC3)CCCCC4=CNC5=C4C=C(C#N)C=C5)=C2)O1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Vilazodone hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.56 20

Preparing Stock Solutions for Vilazodone hydrochloride

The following data is based on the product molecular weight 477.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.46 mL 52.3 mL 104.6 mL
1 mM 2.09 mL 10.46 mL 20.92 mL
2 mM 1.05 mL 5.23 mL 10.46 mL
10 mM 0.21 mL 1.05 mL 2.09 mL

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Product Datasheets for Vilazodone hydrochloride

References for Vilazodone hydrochloride

References are publications that support the biological activity of the product.

Hughes et al (2005) Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. Eur.J.Pharmacol. 510 49 PMID: 15740724

If you know of a relevant reference for Vilazodone hydrochloride, please let us know.

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Keywords: Vilazodone hydrochloride, Vilazodone hydrochloride supplier, SB659746A, EMD68843, Potent, 5-HT1A, partial, agonists, agonism, serotonin-selective, reuptake, inhibitors, inhibits, SSRI, antidepressant, depression, EMD, 68843, SB, 659746A, Receptors, 5-HT, Transporters, 6202, Tocris Bioscience

1 Citation for Vilazodone hydrochloride

Citations are publications that use Tocris products. Selected citations for Vilazodone hydrochloride include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

Do you know of a great paper that uses Vilazodone hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.