Vilazodone hydrochloride

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Cat.No. 6202 - Vilazodone hydrochloride | C26H27N5O2.HCl | CAS No. 163521-08-2
Description: Potent 5-HT1A partial agonist and SSRI; antidepressant
Alternative Names: EMD 68843, SB 659746A
Chemical Name: 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Potent 5-HT1A partial agonist and serotonin-selective reuptake inhibitor (SSRI) (IC50 values are 0.2 and 0.5 nM respectively). Antidepressant.

Technical Data

M. Wt 477.99
Formula C26H27N5O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 163521-08-2
PubChem ID 6918313
Smiles NC(C1=CC2=C(C=CC(N3CCN(CC3)CCCCC4=CNC5=C4C=C(C#N)C=C5)=C2)O1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.56 20

Preparing Stock Solutions

The following data is based on the product molecular weight 477.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.46 mL 52.3 mL 104.6 mL
1 mM 2.09 mL 10.46 mL 20.92 mL
2 mM 1.05 mL 5.23 mL 10.46 mL
10 mM 0.21 mL 1.05 mL 2.09 mL

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References are publications that support the biological activity of the product.

Hughes et al (2005) Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. Eur.J.Pharmacol. 510 49 PMID: 15740724

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