VDM 11

Discontinued Product

VDM 11 (Cat. No. 1392) has been withdrawn from sale for commercial reasons.
Cat.No. 1392 - VDM 11 | C27H39NO2 | CAS No. 313998-81-1
Description: Potent, selective anandamide transport inhibitor
Chemical Name: (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (3)

Biological Activity

A potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC50 values of 4-11 μM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Ki values are > 5-10 μM at CB1 and CB2. Active in vivo. Also available in water-soluble emulsion (Cat. No. 1686).

Technical Data

M. Wt 409.61
Formula C27H39NO2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 313998-81-1
PubChem ID 9887748
InChI Key WUZWFRWVRHLXHZ-ZKWNWVNESA-N
Smiles O=C(NC1=C(C)C=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: VDM 11, VDM 11 supplier, Potent, selective, anandamide, transporters, inhibitors, inhibits, AMT, Cannabinoids, Monoamine, Neurotransmitter, VDM11, Cannabinoid, Transporters, 1392, Tocris Bioscience

5 Citations for VDM 11

Citations are publications that use Tocris products. Selected citations for VDM 11 include:

Hillard et al (2007) Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. Br J Pharmacol 152 691 PMID: 17891162

Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619 PMID: 17408433

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129

Ronesi et al (2004) Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci 24 1673 PMID: 14973237


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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