UVI 3003

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Cat.No. 3303 - UVI 3003 | C28H36O4 | CAS No. 847239-17-2
Description: RXR antagonist
Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.

Technical Data

M. Wt 436.58
Formula C28H36O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 847239-17-2
PubChem ID 44566108
InChI Key APJSHECCIRQQDV-ZRDIBKRKSA-N
Smiles CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(OCCCCC)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.66 100
ethanol 43.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.45 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep. 10 367 PMID: 19270714

Santin et al (2009) Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. J.Med.Chem. 52 3150 PMID: 19408900

Nahoum et al (2007) Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323 PMID:


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Keywords: UVI 3003, supplier, UVI3003, rxr, retinoid, x, receptors, antagonists, Retinoid, X, Receptor, Tocris Bioscience

3 Citations for UVI 3003

Citations are publications that use Tocris products. Selected citations for UVI 3003 include:

Porcu et al (2015) Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation. PLoS One 10 e0144550 PMID: 26658258

Marconett et al (2013) Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet 9 e1003513 PMID: 23818859

Cambray et al (2012) Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors. Nat Commun 3 841 PMID: 22588303


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Pathways for UVI 3003

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