UTPγS trisodium salt

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Cat.No. 3279 - UTPgS trisodium salt | C9H12N2Na3O14P3S | CAS No. 1266569-94-1
Description: Selective P2Y2/4 agonist
Chemical Name: Uridine-5'-(γ-thio)-triphosphate trisodium salt
Datasheet
Citations (1)
Literature

Biological Activity

Selective P2Y2 and P2Y4 receptor agonist. Enzymatically stable.

Technical Data

M. Wt 566.15
Formula C9H12N2Na3O14P3S
Storage Desiccate at -20°C
CAS Number 1266569-94-1
PubChem ID 54591574
InChI Key DBXMFBSCFRDIOA-LLWADOMFSA-K
Smiles [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=S)N1C=CC(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 56.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 566.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.83 mL 17.66 mL
5 mM 0.35 mL 1.77 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lazarowski et al (1996) Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br.J.Pharmacol. 117 203 PMID: 8825364

Malmsjo et al (2000) The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. Br.J.Pharmacol. 131 51 PMID: 10960068

Malmsjo et al (2003) The stable pyrimidines UDPβS and UTPγS discriminate between contractile cerebrovascular P2 receptors. Eur.J.Pharmacol. 458 305 PMID: 12504787


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Keywords: Selective P2Y2/4 agonists Receptors Purinergic purinoceptors UTPgammaS UTPγS trisodium salt Purinergic P2Y Receptors

1 Citation for UTPγS trisodium salt

Citations are publications that use Tocris products. Selected citations for UTPγS trisodium salt include:

Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767 PMID: 25533845


Do you know of a great paper that uses UTPγS trisodium salt from Tocris? If so please let us know.

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Pathways for UTPγS trisodium salt

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