UTPγS trisodium salt

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Cat.No. 3279 - UTPgS trisodium salt | C9H12N2Na3O14P3S | CAS No. 1266569-94-1
Description: Selective P2Y2/4 agonist
Chemical Name: Uridine-5'-(γ-thio)-triphosphate trisodium salt
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Selective P2Y2 and P2Y4 receptor agonist. Enzymatically stable.

Technical Data

M. Wt 566.15
Formula C9H12N2Na3O14P3S
Storage Desiccate at -20°C
CAS Number 1266569-94-1
PubChem ID 54591574
InChI Key DBXMFBSCFRDIOA-LLWADOMFSA-K
Smiles [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=S)N1C=CC(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 56.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 566.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.83 mL 17.66 mL
5 mM 0.35 mL 1.77 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lazarowski et al (1996) Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br.J.Pharmacol. 117 203 PMID: 8825364

Malmsjo et al (2000) The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. Br.J.Pharmacol. 131 51 PMID: 10960068

Malmsjo et al (2003) The stable pyrimidines UDPβS and UTPγS discriminate between contractile cerebrovascular P2 receptors. Eur.J.Pharmacol. 458 305 PMID: 12504787


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Keywords: UTPgS trisodium salt, UTPgS trisodium salt supplier, Selective, P2Y2/4, agonists, Receptors, Purinergic, purinoceptors, UTPgammaS, UTPγS, trisodium, salt, P2Y, 3279, Tocris Bioscience

1 Citation for UTPγS trisodium salt

Citations are publications that use Tocris products. Selected citations for UTPγS trisodium salt include:

Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767 PMID: 25533845


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

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Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.