Discontinued ProductUnfortunately UFP 112 (Cat. No. 2526) has been withdrawn from sale for commercial reasons.
Potent agonist for the nociceptin/orphanin FQ receptor, NOP (ORL1). Displays approximately 100-fold higher potency than N/OFQ and produces longer lasting effects on nociception and locomotor activity in mice. Induces a significant decrease in voluntary ethanol intake in msP rats.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1940.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.52 mL||2.58 mL||5.15 mL|
|5 mM||0.1 mL||0.52 mL||1.03 mL|
|10 mM||0.05 mL||0.26 mL||0.52 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
References are publications that support the products' biological activity.
Economidou et al (2006) Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats. Peptides 27 3299 PMID: 17097763
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Keywords: UFP 112, supplier, nociceptin, orphanin, FQ, receptor, NOP, ORL1, agonist, NOP, Receptors, NOP, Receptors, Tocris Bioscience
Citations for UFP 112
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Currently there are no citations for UFP 112.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.