Potent agonist for the nociceptin/orphanin FQ receptor, NOP (ORL1). Displays approximately 100-fold higher potency than N/OFQ and produces longer lasting effects on nociception and locomotor activity in mice. Induces a significant decrease in voluntary ethanol intake in msP rats.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Economidou et al (2006) Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats. Peptides 27 3299 PMID: 17097763
Rizzi et al (2006) UFP-112, a novel potent and selective peptide agonist for nociceptin/orphanin FQ receptors: in vitro and in vivo studies. Soc.Neurosci.Abstr. 789 16
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Keywords: UFP 112, UFP 112 supplier, nociceptin, orphanin, FQ, receptor, NOP, ORL1, agonist, Receptors, 2526, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.