UF 010

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Cat.No. 5588 - UF 010 | C11H15BrN2O | CAS No. 537672-41-6
Description: Class I HDAC inhibitor
Chemical Name: 4-Bromo-N'-butylbenzohydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Class I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). Exhibits >6-fold selectivity over other HDACs. Induces accumulation of acetylated histones in HCT116 cells in vitro. Inhibits proliferation of a range of cancer cell lines. Arrests cells at G1/S transition.

Compound Libraries

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Technical Data

M. Wt 271.15
Formula C11H15BrN2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 537672-41-6
PubChem ID 4596836
InChI Key BVQCFCYPFJOOAV-UHFFFAOYSA-N
Smiles BrC1=CC=C(C(NNCCCC)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 27.11 100
DMSO 27.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 271.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.44 mL 36.88 mL
5 mM 0.74 mL 3.69 mL 7.38 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2015) Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem.Biol. 22 273 PMID: 25699604


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Literature in this Area

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Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.