UBP1112

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Cat.No. 1369 - UBP1112 | C10H14NO5P | CAS No. 339526-74-8
Description: Group III mGlu antagonist
Chemical Name: α-Methyl-3-methyl-4-phosphonophenylglycine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

A selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).

Technical Data

M. Wt 259.2
Formula C10H14NO5P
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 339526-74-8
PubChem ID 5022489
InChI Key LLEOLNUKLKCAFG-UHFFFAOYSA-N
Smiles NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 259.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.58 mL
5 mM 0.77 mL 3.86 mL 7.72 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Conway et al (2001) Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg.Med.Chem.Lett. 11 777 PMID: 11277518

Miller et al (2003) Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol. 139 1523 PMID: 12922940


If you know of a relevant reference for UBP1112, please let us know.

Keywords: UBP1112, supplier, Group, III, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, UBP, 1112, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

2 Citations for UBP1112

Citations are publications that use Tocris products. Selected citations for UBP1112 include:

Govea et al (2012) Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. J Biol Chem 217 130 PMID: 22609935

Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591 PMID: 16920620


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Pathways for UBP1112

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