Discontinued Product

UBP1112 (Cat. No. 1369) has been withdrawn from sale for commercial reasons.
Description: Group III mGlu antagonist
Chemical Name: α-Methyl-3-methyl-4-phosphonophenylglycine
Purity: ≥99% (HPLC)
Citations (2)
Literature (3)

Biological Activity for UBP1112

UBP1112 is an a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).

Technical Data for UBP1112

M. Wt 259.2
Formula C10H14NO5P
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 339526-74-8
PubChem ID 5022489
Smiles NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for UBP1112

Certificate of Analysis / Product Datasheet
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References for UBP1112

References are publications that support the biological activity of the product.

Conway et al (2001) Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg.Med.Chem.Lett. 11 777 PMID: 11277518

Miller et al (2003) Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol. 139 1523 PMID: 12922940

Keywords: UBP1112, UBP1112 supplier, Group, III, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, UBP, 1112, (Metabotropic), 1369, Tocris Bioscience

2 Citations for UBP1112

Citations are publications that use Tocris products. Selected citations for UBP1112 include:

Govea et al (2012) Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. J Biol Chem 217 130 PMID: 22609935

Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591 PMID: 16920620

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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