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Submit ReviewUAMC 00039 dihydrochloride
Description: Dipeptidyl peptidase II (DPP-II) inhibitor
Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for UAMC 00039 dihydrochloride
UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.
Technical Data for UAMC 00039 dihydrochloride
| M. Wt | 382.76 |
| Formula | C16H24ClN3O.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 697797-51-6 |
| PubChem ID | 24757888 |
| InChI Key | IWXMOQGMIWZNPR-CKUXDGONSA-N |
| Smiles | O=C([C@@H](N)CCNCC2=CC=C(Cl)C=C2)N1CCCCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UAMC 00039 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 38.28 | 100 | |
| DMSO | 38.28 | 100 |
Preparing Stock Solutions for UAMC 00039 dihydrochloride
The following data is based on the product molecular weight 382.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.06 mL | 26.13 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for UAMC 00039 dihydrochloride
References for UAMC 00039 dihydrochloride
References are publications that support the biological activity of the product.
Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737 PMID: 21711053
Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252 PMID: 17287297
If you know of a relevant reference for UAMC 00039 dihydrochloride, please let us know.
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Keywords: UAMC 00039 dihydrochloride, UAMC 00039 dihydrochloride supplier, UAMC00039, dihydrochloride, dipeptidyl, peptidase, II, DPP-II, 2, inhibitors, inhibits, selective, potent, proteases, Other, Proteases, 4954, Tocris Bioscience
1 Citation for UAMC 00039 dihydrochloride
Citations are publications that use Tocris products. Selected citations for UAMC 00039 dihydrochloride include:
Klein et al (2017) Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron 95 281 PMID: 28728022
Do you know of a great paper that uses UAMC 00039 dihydrochloride from Tocris? Please let us know.
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