UAMC 00039 dihydrochloride

Pricing Availability   Qty
Description: Dipeptidyl peptidase II (DPP-II) inhibitor
Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for UAMC 00039 dihydrochloride

UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.

Technical Data for UAMC 00039 dihydrochloride

M. Wt 382.76
Formula C16H24ClN3O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 697797-51-6
PubChem ID 24757888
Smiles O=C([C@@H](N)CCNCC2=CC=C(Cl)C=C2)N1CCCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UAMC 00039 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 38.28 100
DMSO 38.28 100

Preparing Stock Solutions for UAMC 00039 dihydrochloride

The following data is based on the product molecular weight 382.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.06 mL 26.13 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for UAMC 00039 dihydrochloride

References for UAMC 00039 dihydrochloride

References are publications that support the biological activity of the product.

Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737 PMID: 21711053

Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252 PMID: 17287297

If you know of a relevant reference for UAMC 00039 dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: UAMC 00039 dihydrochloride, UAMC 00039 dihydrochloride supplier, UAMC00039, dihydrochloride, dipeptidyl, peptidase, II, DPP-II, 2, inhibitors, inhibits, selective, potent, proteases, Other, Proteases, 4954, Tocris Bioscience

1 Citation for UAMC 00039 dihydrochloride

Citations are publications that use Tocris products. Selected citations for UAMC 00039 dihydrochloride include:

Klein et al (2017) Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron 95 281 PMID: 28728022

Do you know of a great paper that uses UAMC 00039 dihydrochloride from Tocris? Please let us know.

Reviews for UAMC 00039 dihydrochloride

There are currently no reviews for this product. Be the first to review UAMC 00039 dihydrochloride and earn rewards!

Have you used UAMC 00039 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review