UAMC 00039 dihydrochloride

Discontinued Product

UAMC 00039 dihydrochloride (Cat. No. 4954) has been withdrawn from sale for commercial reasons.
Description: Dipeptidyl peptidase II (DPP-II) inhibitor
Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for UAMC 00039 dihydrochloride

UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.

Technical Data for UAMC 00039 dihydrochloride

M. Wt 382.76
Formula C16H24ClN3O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 697797-51-6
PubChem ID 24757888
Smiles O=C([C@@H](N)CCNCC2=CC=C(Cl)C=C2)N1CCCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for UAMC 00039 dihydrochloride

References for UAMC 00039 dihydrochloride

References are publications that support the biological activity of the product.

Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737 PMID: 21711053

Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252 PMID: 17287297

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Keywords: UAMC 00039 dihydrochloride, UAMC 00039 dihydrochloride supplier, UAMC00039, dihydrochloride, dipeptidyl, peptidase, II, DPP-II, 2, inhibitors, inhibits, selective, potent, proteases, Other, Proteases, 4954, Tocris Bioscience

1 Citation for UAMC 00039 dihydrochloride

Citations are publications that use Tocris products. Selected citations for UAMC 00039 dihydrochloride include:

Klein et al (2017) Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron 95 281 PMID: 28728022

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