UAMC 00039 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4954 - UAMC 00039 dihydrochloride | C16H24ClN3O.2HCl | CAS No. 697797-51-6
Description: Dipeptidyl peptidase II (DPP-II) inhibitor
Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.

Compound Libraries

UAMC 00039 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 382.76
Formula C16H24ClN3O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 697797-51-6
PubChem ID 24757888
InChI Key IWXMOQGMIWZNPR-CKUXDGONSA-N
Smiles O=C([C@@H](N)CCNCC2=CC=C(Cl)C=C2)N1CCCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.28 100
ethanol 3.83 10
water 38.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 382.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.06 mL 26.13 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737 PMID: 21711053

Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252 PMID: 17287297


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Citations for UAMC 00039 dihydrochloride

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