U 99194 maleate

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Cat.No. 1357 - U 99194 maleate | C17H27NO2.C4H4O4 | CAS No. 234757-41-6
Description: Potent and selective D3 antagonist
Alternative Names: PNU 99194
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Purity: ≥98% (HPLC)
Citations (2)
Literature (5)

Biological Activity for U 99194 maleate

U 99194 maleate is a potent, selective D3 antagonist. Ki values are 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors respectively.

Technical Data for U 99194 maleate

M. Wt 393.48
Formula C17H27NO2.C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 234757-41-6
PubChem ID 11957713
Smiles OC(=O)\C=C/C(O)=O.CCCN(CCC)C1CC2=C(C1)C=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for U 99194 maleate

Solvent Max Conc. mg/mL Max Conc. mM
water 9.84 25

Preparing Stock Solutions for U 99194 maleate

The following data is based on the product molecular weight 393.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.17 mL 50.83 mL 101.66 mL
1.25 mM 2.03 mL 10.17 mL 20.33 mL
2.5 mM 1.02 mL 5.08 mL 10.17 mL
12.5 mM 0.2 mL 1.02 mL 2.03 mL

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Product Datasheets for U 99194 maleate

Certificate of Analysis / Product Datasheet
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References for U 99194 maleate

References are publications that support the biological activity of the product.

Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel DA D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337

Clifford and Waddington (1998) Heterogeneity of behavioural profile between three putative selective D3 DA receptor antagonists using an ethologically based approach. Psychopharmacology 136 284 PMID: 9566814

LaHoste et al (2000) DA D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J.Neurosci. 20 6666 PMID: 10964971

If you know of a relevant reference for U 99194 maleate, please let us know.

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2 Citations for U 99194 maleate

Citations are publications that use Tocris products. Selected citations for U 99194 maleate include:

Newton et al (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to DA D 2 and D 3 Receptors PLoS One 11 e0158808 PMID: 27379794

Bastianetto et al (2006) Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci 7 28 PMID: 16573831

Do you know of a great paper that uses U 99194 maleate from Tocris? Please let us know.

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Literature in this Area

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