U 99194 maleate

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Cat.No. 1357 - U 99194 maleate | C17H27NO2.C4H4O4 | CAS No. 234757-41-6
Description: Potent, selective D3 antagonist
Alternative Names: PNU 99194
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective D3 antagonist. Ki values are 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors respectively.

Technical Data

M. Wt 393.48
Formula C17H27NO2.C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 234757-41-6
PubChem ID 11957713
InChI Key FSIQDESGRQTFNN-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CCCN(CCC)C1CC2=C(C1)C=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.84 25

Preparing Stock Solutions

The following data is based on the product molecular weight 393.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337

Clifford and Waddington (1998) Heterogeneity of behavioural profile between three putative selective D3 dopamine receptor antagonists using an ethologically based approach. Psychopharmacology 136 284 PMID: 9566814

LaHoste et al (2000) Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J.Neurosci. 20 6666 PMID: 10964971


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Keywords: Potent selective D3 antagonists Dopamine Receptors dopaminergic U99194 maleate PNU99194 PNU 99194 D3 Receptors

1 Citation for U 99194 maleate

Citations are publications that use Tocris products. Selected citations for U 99194 maleate include:

Newton et al (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D 2 and D 3 Receptors PLoS One 11 e0158808 PMID: 27379794


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