U 93631

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Cat.No. 2745 - U 93631 | C17H21N3O2 | CAS No. 152273-12-6
Description: GABAA antagonist
Chemical Name: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.

Technical Data

M. Wt 299.37
Formula C17H21N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 152273-12-6
PubChem ID 197626
InChI Key NXBSEJKZKXIYMD-UHFFFAOYSA-N
Smiles CC(C)(C)OC(=O)C1=C2N(C=N1)C1=CC=CC=C1NC2(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.94 100
ethanol 29.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.7 mL 33.4 mL
5 mM 0.67 mL 3.34 mL 6.68 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References

References are publications that support the biological activity of the product.

Dillon et al (1993) U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 860 PMID: 8232235

Dillon et al (1995) [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J.Pharmacol.Exp.Ther. 272 597 PMID: 7531762

Das et al (2003) The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors. Neuropharmacology 44 431 PMID: 12646280


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Keywords: U 93631, U 93631 supplier, GABAA, receptor, antagonists, Receptors, U93631, 2745, Tocris Bioscience

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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