Tyrphostin B44, (+) enantiomer

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Cat.No. 0579 - Tyrphostin B44, (+) enantiomer | C18H16N2O3 | CAS No. 133550-37-5
Description: EGFR-kinase inhibitor
Chemical Name: (S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Datasheet
Citations
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Literature

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Slightly less active than the (-) enantiomer.

(-)-enantiomer also available.

Technical Data

M. Wt 308.34
Formula C18H16N2O3
Storage Desiccate at +4°C
CAS Number 133550-37-5
PubChem ID 5328769
InChI Key UMGQVUWXNOJOSJ-DGGAMASNSA-N
Smiles OC1=C(O)C=CC(\C=C(C(N[C@@H](C)C2=CC=CC=C2)=O)/C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.25 30

Preparing Stock Solutions

The following data is based on the product molecular weight 308.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428


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Citations for Tyrphostin B44, (+) enantiomer

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