Tyrphostin B44, (-) enantiomer

Discontinued Product

Tyrphostin B44, (-) enantiomer (Cat. No. 0578) has been withdrawn from sale for commercial reasons.
Cat.No. 0578 - Tyrphostin B44, (-) enantiomer | C18H16N2O3 | CAS No. 133550-32-0
Description: EGFR-kinase inhibitor
Chemical Name: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM), more active than the (+) enantiomer. Selective over ErbB2.

(+)-enantiomer also available.

Technical Data

M. Wt 308.34
Formula C18H16N2O3
Storage Desiccate at +4°C
CAS Number 133550-32-0
PubChem ID 5328772
InChI Key UMGQVUWXNOJOSJ-KMHUVPDISA-N
Smiles OC1=C(O)C=CC(\C=C(C(N[C@H](C)C2=CC=CC=C2)=O)/C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428

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Citations for Tyrphostin B44, (-) enantiomer

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