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Tyrphostin B44, (-) enantiomer
Discontinued ProductTyrphostin B44, (-) enantiomer (Cat. No. 0578) has been withdrawn from sale for commercial reasons.
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM), more active than the (+) enantiomer. Selective over ErbB2.
(+)-enantiomer also available.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
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Keywords: Tyrphostin B44, (-) enantiomer, Tyrphostin B44, (-) enantiomer supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factor, Receptors, ErbB, Her, RTK, Receptor, Tyrosine, Kinases, RTKs, (-)-TyrphostinB44, 0578, Tocris Bioscience
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Literature in this Area
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.