Pricing Availability Delivery Time Qty
Cat.No. 6002 - Trolox | C14H18O4 | CAS No. 53188-07-1
Description: Antioxidant vitamin E derivative
Chemical Name: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Purity: ≥98% (HPLC)

Biological Activity

Antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Cell-permeable and water soluble.

Technical Data

M. Wt 250.29
Formula C14H18O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 53188-07-1
PubChem ID 40634
Smiles CC1=C(C(C)=C2CCC(OC2=C1C)(C(O)=O)C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.03 100
ethanol 25.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 250.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 19.98 mL 39.95 mL
5 mM 0.8 mL 4 mL 7.99 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Giulivi et al (1993) Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys. 303 152 PMID: 8489259

Lee et al (2009) Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem. 284 13725 PMID: 19299513

If you know of a relevant reference for Trolox, please let us know.

View Related Products by Target

Keywords: Trolox, supplier, Antioxidant, vitamin, E, derivatives, osteoclast, formation, loss, bone, Antioxidants, Ferroptosis, Antioxidants, Tocris Bioscience

Citations for Trolox

Citations are publications that use Tocris products.

Currently there are no citations for Trolox. Do you know of a great paper that uses Trolox from Tocris? If so please let us know.

Reviews for Trolox

There are currently no reviews for this product. Be the first to review Trolox and earn rewards!

Have you used Trolox?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells