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Biological Activity for Trolox
Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.
Technical Data for Trolox
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Trolox
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Trolox
The following data is based on the product molecular weight 250.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4 mL||19.98 mL||39.95 mL|
|5 mM||0.8 mL||4 mL||7.99 mL|
|10 mM||0.4 mL||2 mL||4 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References for Trolox
References are publications that support the biological activity of the product.
Giulivi et al (1993) Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys. 303 152 PMID: 8489259
Lee et al (2009) Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem. 284 13725 PMID: 19299513
Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443
Cordes et al (2009) On the mechanism of Trolox as antiblinking and antibleaching reagent. J.Am.Chem.Soc. 131 5018 PMID: 19301868
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Keywords: Trolox, Trolox supplier, Antioxidant, vitamin, E, derivatives, osteoclast, formation, loss, bone, antifade, reagents, live, cell, imaging, blinking, photobleaching., Antioxidants, Ferroptosis, Antifade, Reagents, 6002, Tocris Bioscience
Citations for Trolox
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Fluorescent Probes and Dyes Research Product Guide
This product guide provides a comprehensive list and background to the use of Fluorescent Probes and Dyes
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- Fluorogenic Dyes for Light-Up Aptamers
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