Pricing Availability   Qty
Description: Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble
Chemical Name: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for Trolox

Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.

Technical Data for Trolox

M. Wt 250.29
Formula C14H18O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 53188-07-1
PubChem ID 40634
Smiles CC1=C(C(C)=C2CCC(OC2=C1C)(C(O)=O)C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Trolox

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.03 100
ethanol 25.03 100

Preparing Stock Solutions for Trolox

The following data is based on the product molecular weight 250.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 19.98 mL 39.95 mL
5 mM 0.8 mL 4 mL 7.99 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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References for Trolox

References are publications that support the biological activity of the product.

Giulivi et al (1993) Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys. 303 152 PMID: 8489259

Lee et al (2009) Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem. 284 13725 PMID: 19299513

Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443

Cordes et al (2009) On the mechanism of Trolox as antiblinking and antibleaching reagent. J.Am.Chem.Soc. 131 5018 PMID: 19301868

If you know of a relevant reference for Trolox, please let us know.

Keywords: Trolox, Trolox supplier, Antioxidant, vitamin, E, derivatives, osteoclast, formation, loss, bone, antifade, reagents, live, cell, imaging, blinking, photobleaching, hematopoietic, haematopoietic, stem, cells, HSC, Antioxidants, Ferroptosis, Antifade, Reagents, Hematopoietic, Stem, Cells, 6002, Tocris Bioscience

2 Citations for Trolox

Citations are publications that use Tocris products. Selected citations for Trolox include:

Miriam et al (2020) Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep 30 3250-3260.e7 PMID: 32160534

Yi-Sook et al (2020) Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity. Antioxidants (Basel) 9 PMID: 32916895

Do you know of a great paper that uses Trolox from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Dyes and Probes Research Product Guide

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