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Biological Activity for Trolox
Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.
Technical Data for Trolox
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Trolox
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Trolox
The following data is based on the product molecular weight 250.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4 mL||19.98 mL||39.95 mL|
|5 mM||0.8 mL||4 mL||7.99 mL|
|10 mM||0.4 mL||2 mL||4 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References for Trolox
References are publications that support the biological activity of the product.
Giulivi et al (1993) Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys. 303 152 PMID: 8489259
Lee et al (2009) Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem. 284 13725 PMID: 19299513
Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443
Cordes et al (2009) On the mechanism of Trolox as antiblinking and antibleaching reagent. J.Am.Chem.Soc. 131 5018 PMID: 19301868
If you know of a relevant reference for Trolox, please let us know.
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Keywords: Trolox, Trolox supplier, Antioxidant, vitamin, E, derivatives, osteoclast, formation, loss, bone, antifade, reagents, live, cell, imaging, blinking, photobleaching, hematopoietic, haematopoietic, stem, cells, HSC, Antioxidants, Ferroptosis, Antifade, Reagents, Hematopoietic, Stem, Cells, 6002, Tocris Bioscience
2 Citations for Trolox
Citations are publications that use Tocris products. Selected citations for Trolox include:
Miriam et al (2020) Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep 30 3250-3260.e7 PMID: 32160534
Yi-Sook et al (2020) Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity. Antioxidants (Basel) 9 PMID: 32916895
Do you know of a great paper that uses Trolox from Tocris? Please let us know.
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Literature in this Area
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