Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 139.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.19 mL||35.93 mL||71.85 mL|
|5 mM||1.44 mL||7.19 mL||14.37 mL|
|10 mM||0.72 mL||3.59 mL||7.19 mL|
|50 mM||0.14 mL||0.72 mL||1.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Fariello et al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241 PMID: 7199633
Gervais et al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537 PMID: 16675063
If you know of a relevant reference for Tramiprosate, please let us know.
Keywords: Sulfated glycosaminoglycan sGAG Targets soluble Amyloid-beta β-Amyloid beta-Amyloid b-amyloid decrease amyloid plaque deposition Precursor Protein APP Secretase beta Peptides GABAA GABAC GABAB Receptors analogue amyloidb amyloidβ Homotaurine Amyloid Beta Peptides
Citations for Tramiprosate
Citations are publications that use Tocris products.
Currently there are no citations for Tramiprosate. Do you know of a great paper that uses Tramiprosate from Tocris? If so please let us know.
Literature in this Area
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