Tramiprosate

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Cat.No. 3619 - Tramiprosate | C3H9NO3S | CAS No. 3687-18-1
Description: Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
Alternative Names: Homotaurine
Chemical Name: 3-Amino-1-propanesulfonic acid
Datasheet
Citations
Reviews
Literature

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

Technical Data

M. Wt 139.17
Formula C3H9NO3S
Storage Store at +4°C
CAS Number 3687-18-1
PubChem ID 1646
InChI Key SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Smiles NCCCS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 139.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.19 mL 35.93 mL 71.85 mL
5 mM 1.44 mL 7.19 mL 14.37 mL
10 mM 0.72 mL 3.59 mL 7.19 mL
50 mM 0.14 mL 0.72 mL 1.44 mL

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References

References are publications that support the biological activity of the product.

Fariello et al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241 PMID: 7199633

Gervais et al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537 PMID: 16675063

Santa-Maria et al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 2 17


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