TP 472

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Cat.No. 6000 - TP 472 | C20H19N3O2 | CAS No. 2079895-62-6
Description: Potent BRD9/7 inhibitor
Chemical Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity for TP 472

TP 472 is a potent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.

Compound Libraries for TP 472

TP 472 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TP 472

M. Wt 333.38
Formula C20H19N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2079895-62-6
PubChem ID 123773279
InChI Key RPBMXJHQYJLPDN-UHFFFAOYSA-N
Smiles O=C(C)C1=CC(C2=CC(C(NC3CC3)=O)=CC=C2C)=C4N=CC=CN41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TP 472

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.67 50

Preparing Stock Solutions for TP 472

The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6 mL 30 mL 59.99 mL
2.5 mM 1.2 mL 6 mL 12 mL
5 mM 0.6 mL 3 mL 6 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

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References for TP 472

References are publications that support the biological activity of the product.

Hohmann and Vakoc et al (2014) A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 30 356 PMID: 24932742


If you know of a relevant reference for TP 472, please let us know.

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Keywords: TP 472, TP 472 supplier, TP472, bromodomains, BRD9, BRD7, inhibitors, potent, CAS, 2079895-62-6, Bromodomains, 6000, Tocris Bioscience

1 Citation for TP 472

Citations are publications that use Tocris products. Selected citations for TP 472 include:

Gatchalian et al (2018) A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun 9 5139 PMID: 30510198


Do you know of a great paper that uses TP 472 from Tocris? Please let us know.

Reviews for TP 472

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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