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Description: Potent BRD9/7 inhibitor
Chemical Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
Purity: ≥98% (HPLC)
Biological Activity
Potent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.
Negative Control also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.
Technical Data
| M. Wt | 333.38 |
| Formula | C20H19N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 123773279 |
| InChI Key | RPBMXJHQYJLPDN-UHFFFAOYSA-N |
| Smiles | O=C(C)C1=CC(C2=CC(C(NC3CC3)=O)=CC=C2C)=C4N=CC=CN41 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.67 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6 mL | 30 mL | 59.99 mL |
| 2.5 mM | 1.2 mL | 6 mL | 12 mL |
| 5 mM | 0.6 mL | 3 mL | 6 mL |
| 25 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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References
References are publications that support the biological activity of the product.
Hohmann and Vakoc et al (2014) A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 30 356 PMID: 24932742
If you know of a relevant reference for TP 472, please let us know.
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Keywords: TP 472, TP 472 supplier, TP472, bromodomains, BRD9, BRD7, inhibitors, potent, CAS, 2079895-62-6, Bromodomains, 6000, Tocris Bioscience
Citations for TP 472
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Epigenetics Scientific Review
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