Adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 291.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.43 mL||17.17 mL||34.33 mL|
|5 mM||0.69 mL||3.43 mL||6.87 mL|
|10 mM||0.34 mL||1.72 mL||3.43 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
References are publications that support the biological activity of the product.
Ri et al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79 PMID: 22852048
Nishioka et al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586 PMID: 2177464
Yen et al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797 PMID: 16556935
If you know of a relevant reference for Toyocamycin, please let us know.
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Keywords: Toyocamycin, Toyocamycin supplier, Toyocamycin, antibiotics, adenosine, analog, antifungal, anticancer, PI3K, phosphoinositide, 3-kinases, phosphatidylinositol, inhibitors, inhibits, Antibiotics, 5270, Tocris Bioscience
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