Adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 291.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.43 mL||17.17 mL||34.33 mL|
|5 mM||0.69 mL||3.43 mL||6.87 mL|
|10 mM||0.34 mL||1.72 mL||3.43 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
References are publications that support the biological activity of the product.
Ri et al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79 PMID: 22852048
Nishioka et al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586 PMID: 2177464
Yen et al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797 PMID: 16556935
If you know of a relevant reference for Toyocamycin, please let us know.
View Related Products by Target
Keywords: Toyocamycin, Toyocamycin supplier, Toyocamycin, antibiotics, adenosine, analog, antifungal, anticancer, PI3K, phosphoinositide, 3-kinases, phosphatidylinositol, inhibitors, inhibits, Antibiotics, 5270, Tocris Bioscience
Citations for Toyocamycin
Citations are publications that use Tocris products.
Currently there are no citations for Toyocamycin. Do you know of a great paper that uses Toyocamycin from Tocris? Please let us know.
Reviews for Toyocamycin
There are currently no reviews for this product. Be the first to review Toyocamycin and earn rewards!
Have you used Toyocamycin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells