Toceranib

Pricing Availability Delivery Time Qty
Cat.No. 3909 - Toceranib | C22H25FN4O2 | CAS No. 356068-94-5
Description: Potent PDGFR and VEGFR inhibitor
Alternative Names: Palladia
Chemical Name: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer.

Technical Data

M. Wt 396.46
Formula C22H25FN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 356068-94-5
PubChem ID 5329106
InChI Key SRSGVKWWVXWSJT-ATVHPVEESA-N
Smiles O=C2NC1=CC=C(F)C=C1/C2=C/C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.96 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 396.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Liao et al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585 PMID: 12091352


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View all PDGFR Inhibitors

Keywords: Toceranib, Toceranib supplier, Potent, PDGFR, VEGFR, inhibitors, inhibits, c-kit, FGFR1, mast, cell, cycle, arrest, apoptosis, tumors, tumours, Palladia, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 3909, Tocris Bioscience

Citations for Toceranib

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