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Biological Activity for Toceranib
Toceranib is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.
Sold for research purposes under agreement from Pfizer.
Technical Data for Toceranib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Toceranib
References are publications that support the biological activity of the product.
Liao et al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585 PMID: 12091352
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Keywords: Toceranib, Toceranib supplier, Potent, PDGFR, VEGFR, inhibitors, inhibits, c-kit, FGFR1, mast, cell, cycle, arrest, apoptosis, tumors, tumours, Palladia, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 3909, Tocris Bioscience
Citations for Toceranib
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Currently there are no citations for Toceranib.
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Literature in this Area
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