Toceranib

Discontinued Product

Toceranib (Cat. No. 3909) has been withdrawn from sale for commercial reasons.
Cat.No. 3909 - Toceranib | C22H25FN4O2 | CAS No. 356068-94-5
Description: Potent PDGFR and VEGFR inhibitor
Alternative Names: Palladia
Chemical Name: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Toceranib

Toceranib is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer.

Technical Data for Toceranib

M. Wt 396.46
Formula C22H25FN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 356068-94-5
PubChem ID 5329106
InChI Key SRSGVKWWVXWSJT-ATVHPVEESA-N
Smiles O=C2NC1=CC=C(F)C=C1/C2=C/C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Toceranib

Certificate of Analysis / Product Datasheet
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References for Toceranib

References are publications that support the biological activity of the product.

Liao et al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585 PMID: 12091352

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Keywords: Toceranib, Toceranib supplier, Potent, PDGFR, VEGFR, inhibitors, inhibits, c-kit, FGFR1, mast, cell, cycle, arrest, apoptosis, tumors, tumours, Palladia, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 3909, Tocris Bioscience

Citations for Toceranib

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Currently there are no citations for Toceranib.

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Literature in this Area

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