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TNP

Cat. No. 3946 Submit a Review Datasheet / COA / SDS
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Description: Inhibitor of IP6K; also inhibits IP3K
Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TNP

TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).

Technical Data for TNP

M. Wt 443.38
Formula C20H16F3N7O2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 519178-28-0
PubChem ID 16760513
InChI Key DDSBPUYZPWNNGH-UHFFFAOYSA-N
Smiles O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TNP

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.34 100
ethanol 11.08 25

Preparing Stock Solutions for TNP

The following data is based on the product molecular weight 443.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

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Product Datasheets for TNP

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for TNP

References are publications that support the biological activity of the product.

Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571 PMID: 19208622

Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897 PMID: 12210991

If you know of a relevant reference for TNP, please let us know.

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Keywords: TNP, TNP supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Other, Kinases, Inositol, Lipids, 3946, Tocris Bioscience

Citations for TNP

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