TNP

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Cat.No. 3946 - TNP | C20H16F3N7O2 | CAS No. 519178-28-0
Description: Inhibitor of IP6K; also inhibits IP3K
Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).

Technical Data

M. Wt 443.38
Formula C20H16F3N7O2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 519178-28-0
PubChem ID 16760513
InChI Key DDSBPUYZPWNNGH-UHFFFAOYSA-N
Smiles O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.34 100
ethanol 11.08 25

Preparing Stock Solutions

The following data is based on the product molecular weight 443.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571 PMID: 19208622

Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897 PMID: 12210991


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Keywords: TNP, supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Other, Kinases, Inositol, Lipids, Other, Kinases, Tocris Bioscience

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