Discontinued ProductUnfortunately TNP 470 (Cat. No. 3750) has been withdrawn from sale for commercial reasons.
Analog of Fumagillin (Cat. No. 1768) that displays potent antiangiogenic activity in vitro and in vivo. Inhibits methionine aminopeptidase type II (MetAP2). Potently inhibits the proliferation of endothelial cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 401.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.49 mL||12.44 mL||24.88 mL|
|5 mM||0.5 mL||2.49 mL||4.98 mL|
|10 mM||0.25 mL||1.24 mL||2.49 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Arico-Muendel et al (2009) Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2. J.Med.Chem. 52 8047 PMID: 19929003
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Keywords: TNP470 methionine aminopeptidase-2 MetAP2 proteases proteinases antiangiogenics angiogenesis AGM1470 AGM 1470 Aminopeptidases
Citations for TNP 470
Citations are publications that use Tocris products.
Currently there are no citations for TNP 470.
Literature in this Area
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