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Analog of Fumagillin (Cat. No. 1768) that displays potent antiangiogenic activity in vitro and in vivo. Inhibits methionine aminopeptidase type II (MetAP2). Potently inhibits the proliferation of endothelial cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Arico-Muendel et al (2009) Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2. J.Med.Chem. 52 8047 PMID: 19929003
Huang et al (2003) TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol.Cancer Ther. 3 335
Miura et al (2004) Carcinosarcoma-induced endothelial cells tube formation through KDR/FLK-1 is blocked by TNP-470. Cancer Letts. 203 45
Hines et al (2010) Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. J.Pharm.Exp.Ther. 334 729
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Keywords: TNP 470, TNP 470 supplier, TNP470, methionine, aminopeptidase-2, MetAP2, proteases, proteinases, antiangiogenics, angiogenesis, AGM1470, AGM, 1470, Aminopeptidases, Antiangiogenics, 3750, Tocris Bioscience
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