TNP 470

Discontinued Product

TNP 470 (Cat. No. 3750) has been withdrawn from sale for commercial reasons.
Cat.No. 3750 - TNP 470 | C19H28ClNO6 | CAS No. 129298-91-5
Description: Methionine aminopeptidase-2 inhibitor; antiangiogenic
Alternative Names: AGM 1470
Chemical Name: N-(2-Chloroacetyl)carbamic acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Analog of Fumagillin (Cat. No. 1768) that displays potent antiangiogenic activity in vitro and in vivo. Inhibits methionine aminopeptidase type II (MetAP2). Potently inhibits the proliferation of endothelial cells.

Technical Data

M. Wt 401.88
Formula C19H28CINO6
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 129298-91-5
Smiles [H][C@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@H](OC)[C@H](OC(NC(CCl)=O)=O)CC[C@@]21CO2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Arico-Muendel et al (2009) Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2. J.Med.Chem. 52 8047 PMID: 19929003

Huang et al (2003) TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol.Cancer Ther. 3 335

Miura et al (2004) Carcinosarcoma-induced endothelial cells tube formation through KDR/FLK-1 is blocked by TNP-470. Cancer Letts. 203 45

Hines et al (2010) Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. J.Pharm.Exp.Ther. 334 729

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Keywords: TNP 470, TNP 470 supplier, TNP470, methionine, aminopeptidase-2, MetAP2, proteases, proteinases, antiangiogenics, angiogenesis, AGM1470, AGM, 1470, Aminopeptidases, Antiangiogenics, 3750, Tocris Bioscience

Citations for TNP 470

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Literature in this Area

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