TNP 470

Discontinued Product

Unfortunately TNP 470 (Cat. No. 3750) has been withdrawn from sale for commercial reasons.
Cat.No. 3750 - TNP 470 | C19H28ClNO6 | CAS No. 129298-91-5
Description: Methionine aminopeptidase-2 inhibitor; antiangiogenic
Alternative Names: AGM 1470
Chemical Name: N-(2-Chloroacetyl)carbamic acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
Purity: ≥97% (HPLC)

Biological Activity

Analog of Fumagillin (Cat. No. 1768) that displays potent antiangiogenic activity in vitro and in vivo. Inhibits methionine aminopeptidase type II (MetAP2). Potently inhibits the proliferation of endothelial cells.

Technical Data

M. Wt 401.88
Formula C19H28CINO6
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 129298-91-5
Smiles [H][C@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@H](OC)[C@H](OC(NC(CCl)=O)=O)CC[C@@]21CO2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 401.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.88 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Arico-Muendel et al (2009) Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2. J.Med.Chem. 52 8047 PMID: 19929003

Huang et al (2003) TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol.Cancer Ther. 3 335 PMID:

Miura et al (2004) Carcinosarcoma-induced endothelial cells tube formation through KDR/FLK-1 is blocked by TNP-470. Cancer Letts. 203 45 PMID:

Hines et al (2010) Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. J.Pharm.Exp.Ther. 334 729 PMID:

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Keywords: TNP470 methionine aminopeptidase-2 MetAP2 proteases proteinases antiangiogenics angiogenesis AGM1470 AGM 1470 Aminopeptidases

Citations for TNP 470

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