Fumagillin

Pricing Availability   Qty
Cat.No. 1768 - Fumagillin | C26H34O7 | CAS No. 23110-15-8
Description: Methionine aminopeptidase-2 inhibitor; antiangiogenic
Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.

Technical Data

M. Wt 458.55
Formula C26H34O7
Storage Store at -20°C
CAS Number 23110-15-8
PubChem ID 6917655
InChI Key NGGMYCMLYOUNGM-CSDLUJIJSA-N
Smiles [H][C@@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@@]2(CO2)CC[C@@H](OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)[C@H]1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.15 2.5

Preparing Stock Solutions

The following data is based on the product molecular weight 458.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.025 mM 87.23 mL 436.16 mL 872.31 mL
0.125 mM 17.45 mL 87.23 mL 174.46 mL
0.25 mM 8.72 mL 43.62 mL 87.23 mL
1.25 mM 1.74 mL 8.72 mL 17.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153 PMID: 9770455

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555 PMID: 1701033

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327 PMID: 4630977

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457 PMID: 11848509


If you know of a relevant reference for Fumagillin, please let us know.

View Related Products by Product Action

View all Aminopeptidase Inhibitors

Keywords: Fumagillin, Fumagillin supplier, Methionine, aminopeptidase-2, inhibitors, inhibits, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Antiangiogenics, Antibiotics, Aminopeptidases, 1768, Tocris Bioscience

1 Citation for Fumagillin

Citations are publications that use Tocris products. Selected citations for Fumagillin include:

Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891 PMID: 21943108


Do you know of a great paper that uses Fumagillin from Tocris? Please let us know.

Reviews for Fumagillin

There are currently no reviews for this product. Be the first to review Fumagillin and earn rewards!

Have you used Fumagillin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells