Discontinued Product

Fumagillin (Cat. No. 1768) has been withdrawn from sale for commercial reasons.
Description: Methionine aminopeptidase-2 inhibitor; antiangiogenic
Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Citations (1)

Biological Activity for Fumagillin

Fumagillin is an antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.

Technical Data for Fumagillin

M. Wt 458.55
Formula C26H34O7
Storage Store at -20°C
CAS Number 23110-15-8
PubChem ID 6917655
Smiles [H][C@@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@@]2(CO2)CC[C@@H](OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)[C@H]1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Fumagillin

Certificate of Analysis / Product Datasheet
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References for Fumagillin

References are publications that support the biological activity of the product.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153 PMID: 9770455

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555 PMID: 1701033

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327 PMID: 4630977

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457 PMID: 11848509

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Keywords: Fumagillin, Fumagillin supplier, Methionine, aminopeptidase-2, inhibitors, inhibits, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Antiangiogenics, Antibiotics, Aminopeptidases, 1768, Tocris Bioscience

1 Citation for Fumagillin

Citations are publications that use Tocris products. Selected citations for Fumagillin include:

Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891 PMID: 21943108

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