Fumagillin

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Cat.No. 1768 - Fumagillin | C26H34O7 | CAS No. 23110-15-8
Description: Methionine aminopeptidase-2 inhibitor; antiangiogenic
Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Datasheet
Citations (1)
Literature

Biological Activity

Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.

Technical Data

M. Wt 458.55
Formula C26H34O7
Storage Store at -20°C
CAS Number 23110-15-8
PubChem ID 6917655
InChI Key NGGMYCMLYOUNGM-CSDLUJIJSA-N
Smiles [H][C@@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@@]2(CO2)CC[C@@H](OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)[C@H]1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.15 2.5

Preparing Stock Solutions

The following data is based on the product molecular weight 458.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.9 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153 PMID: 9770455

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555 PMID: 1701033

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327 PMID: 4630977

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457 PMID: 11848509


If you know of a relevant reference for Fumagillin, please let us know.

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View all Aminopeptidase Inhibitors

Keywords: Methionine aminopeptidase-2 inhibitors inhibits Proteases Proteinases antiangiogenics angiogenesis antibiotics Aminopeptidases

1 Citation for Fumagillin

Citations are publications that use Tocris products. Selected citations for Fumagillin include:

Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891 PMID: 21943108


Do you know of a great paper that uses Fumagillin from Tocris? If so please let us know.

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Pathways for Fumagillin

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