You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 458.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.025 mM||87.23 mL||436.16 mL||872.31 mL|
|0.125 mM||17.45 mL||87.23 mL||174.46 mL|
|0.25 mM||8.72 mL||43.62 mL||87.23 mL|
|1.25 mM||1.74 mL||8.72 mL||17.45 mL|
References are publications that support the biological activity of the product.
Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153 PMID: 9770455
Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555 PMID: 1701033
Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327 PMID: 4630977
Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457 PMID: 11848509
If you know of a relevant reference for Fumagillin, please let us know.
View Related Products by Product Action
Keywords: Fumagillin, Fumagillin supplier, Methionine, aminopeptidase-2, inhibitors, inhibits, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Antiangiogenics, Antibiotics, Aminopeptidases, 1768, Tocris Bioscience
1 Citation for Fumagillin
Citations are publications that use Tocris products. Selected citations for Fumagillin include:
Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891 PMID: 21943108
Do you know of a great paper that uses Fumagillin from Tocris? Please let us know.
Reviews for Fumagillin
There are currently no reviews for this product. Be the first to review Fumagillin and earn rewards!
Have you used Fumagillin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells