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Discontinued ProductFumagillin (Cat. No. 1768) has been withdrawn from sale for commercial reasons.
Biological Activity for Fumagillin
Fumagillin is an antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.
Technical Data for Fumagillin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Fumagillin
References are publications that support the biological activity of the product.
Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153 PMID: 9770455
Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555 PMID: 1701033
Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327 PMID: 4630977
Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457 PMID: 11848509
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Keywords: Fumagillin, Fumagillin supplier, Methionine, aminopeptidase-2, inhibitors, inhibits, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Antiangiogenics, Antibiotics, Aminopeptidases, 1768, Tocris Bioscience
1 Citation for Fumagillin
Citations are publications that use Tocris products. Selected citations for Fumagillin include:
Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891 PMID: 21943108
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