TM2 TEAD inhibitor

Pricing Availability   Qty
Description: Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling
Chemical Name: 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)

Biological Activity for TM2 TEAD inhibitor

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.

Technical Data for TM2 TEAD inhibitor

M. Wt 435.57
Formula C26H33N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1008768-41-9
PubChem ID 68301145
InChI Key LWLAYULJAJMPKG-UHFFFAOYSA-N
Smiles O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TM2 TEAD inhibitor

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.56 100
ethanol 43.56 100

Preparing Stock Solutions for TM2 TEAD inhibitor

The following data is based on the product molecular weight 435.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for TM2 TEAD inhibitor

References for TM2 TEAD inhibitor

References are publications that support the biological activity of the product.

Hu et al (2022) Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. eLife 11 e80210 PMID: 36398861


If you know of a relevant reference for TM2 TEAD inhibitor, please let us know.

View Related Products by Product Action

View all Hippo and YAP/TAZ Signaling Inhibitors

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Citations for TM2 TEAD inhibitor

Citations are publications that use Tocris products.

Currently there are no citations for TM2 TEAD inhibitor. Do you know of a great paper that uses TM2 TEAD inhibitor from Tocris? Please let us know.

Reviews for TM2 TEAD inhibitor

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for TM2 TEAD inhibitor

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
Notch Signaling Pathway

Notch Signaling Pathway

The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.
Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.