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Thiolutin is an antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729 PMID: 4597739
Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307 PMID: 11433393
O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163 PMID: 11036042
Keywords: Thiolutin, Thiolutin supplier, Bacterial, RNA, polymerases, inhibitors, inhibits, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam, Cell, Polymerase, 1567, Tocris Bioscience
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Currently there are no citations for Thiolutin.
Average Rating: 5 (Based on 1 Review.)
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