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Cat.No. 1567 - Thiolutin | C8H8N2O2S2 | CAS No. 87-11-6
Description: Bacterial RNA polymerase inhibitor
Chemical Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity

Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.

Technical Data

M. Wt 228.28
Formula C8H8N2O2S2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 87-11-6
PubChem ID 6870
Smiles O=C(N2C)C(NC(C)=O)=C1C2=CSS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5 22

Preparing Stock Solutions

The following data is based on the product molecular weight 228.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.22 mM 19.91 mL 99.56 mL 199.12 mL
1.1 mM 3.98 mL 19.91 mL 39.82 mL
2.2 mM 1.99 mL 9.96 mL 19.91 mL
11 mM 0.4 mL 1.99 mL 3.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729 PMID: 4597739

Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307 PMID: 11433393

O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163 PMID: 11036042

If you know of a relevant reference for Thiolutin, please let us know.

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Keywords: Thiolutin, Thiolutin supplier, Bacterial, RNA, polymerases, inhibitors, inhibits, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam, Cell, Polymerase, 1567, Tocris Bioscience

Citations for Thiolutin

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Study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis.
By Anonymous on 02/13/2019
Species: Human

Used in study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis.

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Literature in this Area

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