You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 228.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.22 mM||19.91 mL||99.56 mL||199.12 mL|
|1.1 mM||3.98 mL||19.91 mL||39.82 mL|
|2.2 mM||1.99 mL||9.96 mL||19.91 mL|
|11 mM||0.4 mL||1.99 mL||3.98 mL|
References are publications that support the biological activity of the product.
Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729 PMID: 4597739
Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307 PMID: 11433393
O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163 PMID: 11036042
If you know of a relevant reference for Thiolutin, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Thiolutin, Thiolutin supplier, Bacterial, RNA, polymerases, inhibitors, inhibits, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam, Cell, RNA/DNA, Polymerase, 1567, Tocris Bioscience
Citations for Thiolutin
Citations are publications that use Tocris products.
Currently there are no citations for Thiolutin. Do you know of a great paper that uses Thiolutin from Tocris? Please let us know.
Reviews for Thiolutin
Average Rating: 5 (Based on 1 Review.)
Have you used Thiolutin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.