Potent and selective PI 3-kinase β inhibitor (IC50 values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.72 mL||27.44 mL|
|5 mM||0.55 mL||2.74 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the products' biological activity.
Condliffe et al (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979
Jackson et al (2005) PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 11 507 PMID: 15834429
If you know of a relevant reference for TGX 221, please let us know.
View Related Products by Product Action
Keywords: TGX 221, supplier, TGX221, PI3K, PI, 3-kinase, phosphoinositide, potent, selective, inhibits, inhibitors, beta, β, antithrombotic, PI, 3-Kinase, PI, 3-Kinase, Tocris Bioscience
Citations for TGX 221
Citations are publications that use Tocris products.
Currently there are no citations for TGX 221. Do you know of a great paper that uses TGX 221 from Tocris? If so please let us know.
Reviews for TGX 221
There are currently no reviews for this product. Be the first to review TGX 221 and earn rewards!
Have you used TGX 221?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.