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Potent and selective PI 3-kinase β inhibitor (IC50 values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.49 mL||27.44 mL||54.88 mL|
|2.5 mM||1.1 mL||5.49 mL||10.98 mL|
|5 mM||0.55 mL||2.74 mL||5.49 mL|
|25 mM||0.11 mL||0.55 mL||1.1 mL|
References are publications that support the biological activity of the product.
Condliffe et al (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979
Jackson et al (2005) PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 11 507 PMID: 15834429
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Keywords: TGX 221, TGX 221 supplier, TGX221, PI3K, PI, 3-kinase, phosphoinositide, potent, selective, inhibits, inhibitors, beta, β, antithrombotic, 3-Kinase, 5832, Tocris Bioscience
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Literature in this Area
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