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Tertiapin LQ

Cat. No. 4339 Submit a Review Datasheet / COA / SDS

Discontinued Product

Tertiapin LQ (Cat. No. 4339) has been withdrawn from sale for commercial reasons.
Description: Selective Kir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Datasheets References

Biological Activity for Tertiapin LQ

Tertiapin LQ is a blocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q (Cat. No. 1316).

Technical Data for Tertiapin LQ

M. Wt 2428.03
Formula C106H179N33O24S4
Sequence ALCNCNRIIIPLQCWKKCGKK

(Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide)
Storage Store at -20°C
PubChem ID 90488935
InChI Key WUMIWMIQOSXVPZ-ZPWFPUPGSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC2=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Tertiapin LQ

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Tertiapin LQ

References are publications that support the biological activity of the product.

Ramu et al (2008) Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc.Natl.Acad.Sci.USA 105 10774 PMID: 18669667

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Citations for Tertiapin LQ

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