Telmisartan

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Cat.No. 5139 - Telmisartan | C33H30N4O2 | CAS No. 144701-48-4
Description: AT1 antagonist; PPARγ partial agonist
Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.

Compound Libraries

Telmisartan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 514.62
Formula C33H30N4O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144701-48-4
PubChem ID 65999
InChI Key RMMXLENWKUUMAY-UHFFFAOYSA-N
Smiles CCCC4=NC(C(C)=C3)=C(N4CC5=CC=C(C6=CC=CC=C6C(O)=O)C=C5)C=C3C2=NC1=CC=CC=C1N2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.29 20

Preparing Stock Solutions

The following data is based on the product molecular weight 514.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.72 mL 48.58 mL 97.16 mL
1 mM 1.94 mL 9.72 mL 19.43 mL
2 mM 0.97 mL 4.86 mL 9.72 mL
10 mM 0.19 mL 0.97 mL 1.94 mL

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References

References are publications that support the biological activity of the product.

Rong et al (2009) An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096 PMID: 19770292

Benson et al (2004) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993 PMID: 15007034

Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040 PMID: 8258826


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View Related Products by Product Action

View all Angiotensin AT1 Receptor Antagonists

Keywords: Telmisartan, Telmisartan supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Angiotensin, Receptors, 5139, Tocris Bioscience

1 Citation for Telmisartan

Citations are publications that use Tocris products. Selected citations for Telmisartan include:

Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709 PMID: 26316709


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Literature in this Area

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