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Telmisartan is an antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.
Telmisartan is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 514.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.72 mL||48.58 mL||97.16 mL|
|1 mM||1.94 mL||9.72 mL||19.43 mL|
|2 mM||0.97 mL||4.86 mL||9.72 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
References are publications that support the biological activity of the product.
Rong et al (2009) An adipose tissue-independent Ins-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096 PMID: 19770292
Benson et al (2004) Identification of telmis. as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993 PMID: 15007034
Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040 PMID: 8258826
If you know of a relevant reference for Telmisartan, please let us know.
Keywords: Telmisartan, Telmisartan supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Angiotensin, Receptors, 5139, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Telmisartan include:
Lin et al (2015) Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709 PMID: 26316709
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