Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 514.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.94 mL||9.72 mL||19.43 mL|
|5 mM||0.39 mL||1.94 mL||3.89 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Rong et al (2009) An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096 PMID: 19770292
Benson et al (2004) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993 PMID: 15007034
Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040 PMID: 8258826
If you know of a relevant reference for Telmisartan, please let us know.
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Keywords: Telmisartan, supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Angiotensin, AT1, Receptors, PPARgamma, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience
1 Citation for Telmisartan
Citations are publications that use Tocris products. Selected citations for Telmisartan include:
Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709 PMID: 26316709
Do you know of a great paper that uses Telmisartan from Tocris? If so please let us know.