Discontinued Product

Telmisartan (Cat. No. 5139) has been withdrawn from sale for commercial reasons.
Description: AT1 antagonist; PPARγ partial agonist
Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for Telmisartan

Telmisartan is an antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.

Compound Libraries for Telmisartan

Telmisartan is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Telmisartan

M. Wt 514.62
Formula C33H30N4O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144701-48-4
PubChem ID 65999
Smiles CCCC4=NC(C(C)=C3)=C(N4CC5=CC=C(C6=CC=CC=C6C(O)=O)C=C5)C=C3C2=NC1=CC=CC=C1N2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Telmisartan

References are publications that support the biological activity of the product.

Rong et al (2009) An adipose tissue-independent Ins-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096 PMID: 19770292

Benson et al (2004) Identification of telmis. as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993 PMID: 15007034

Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040 PMID: 8258826

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Keywords: Telmisartan, Telmisartan supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Angiotensin, Receptors, 5139, Tocris Bioscience

2 Citations for Telmisartan

Citations are publications that use Tocris products. Selected citations for Telmisartan include:

Josef M et al (2018) Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci 75 3625-3634 PMID: 29679094

Lin et al (2015) Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709 PMID: 26316709

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