Pricing Availability   Qty
Description: Selective, ATP-competitive Pim-1 kinase inhibitor
Alternative Names: SC 204330
Chemical Name: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Purity: ≥98% (HPLC)

Biological Activity for TCS PIM-1 1

TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

Compound Libraries for TCS PIM-1 1

TCS PIM-1 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS PIM-1 1

M. Wt 367.2
Formula C18H11BrN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 491871-58-0
PubChem ID 1235170
Smiles OC1=C(C2=CC(C3=CC=CC=C3)=C(C#N)C(N2)=O)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS PIM-1 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.72 100

Preparing Stock Solutions for TCS PIM-1 1

The following data is based on the product molecular weight 367.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.62 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for TCS PIM-1 1

Certificate of Analysis / Product Datasheet
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References for TCS PIM-1 1

References are publications that support the biological activity of the product.

Cheney et al (2007) Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Letts. 17 1679 PMID: 17251021

If you know of a relevant reference for TCS PIM-1 1, please let us know.

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Keywords: TCS PIM-1 1, TCS PIM-1 1 supplier, Selective, ATP-competitive, Pim-1, kinases, inhibitors, inhibits, TCSPIM11, SC, 204330, Pim, Kinase, 2979, Tocris Bioscience

Citations for TCS PIM-1 1

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