TCS PIM-1 1

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Cat.No. 2979 - TCS PIM-1 1 | C18H11BrN2O2 | CAS No. 491871-58-0
Description: Selective, ATP-competitive Pim-1 kinase inhibitor
Chemical Name: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

Compound Libraries

TCS PIM-1 1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 367.2
Formula C18H11BrN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 491871-58-0
PubChem ID 1235170
InChI Key SVSYJTYGPLVUOZ-UHFFFAOYSA-N
Smiles OC1=C(C2=CC(C3=CC=CC=C3)=C(C#N)C(N2)=O)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 367.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.62 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cheney et al (2007) Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Letts. 17 1679 PMID: 17251021


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Keywords: TCS PIM-1 1, supplier, Selective, ATP-competitive, Pim-1, kinases, inhibitors, inhibits, TCSPIM11, Pim, Kinase, Pim, Kinase, Tocris Bioscience

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Literature in this Area

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Pathways for TCS PIM-1 1

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