TCS 5861528

Pricing Availability Delivery Time Qty
Cat.No. 3938 - TCS 5861528 | C19H23N5O3 | CAS No. 332117-28-9
Description: TRPA1 blocker
Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Compound Libraries

TCS 5861528 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 369.42
Formula C19H23N5O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 332117-28-9
PubChem ID 2873523
InChI Key ZUTUWJYMCADJHD-UHFFFAOYSA-N
Smiles O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.94 100
ethanol 3.69 10

Preparing Stock Solutions

The following data is based on the product molecular weight 369.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wei et al (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111 147 PMID: 19512877

Wei et al (2010) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58 578 PMID: 20004676

Wei et al (2010) Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. 479 253 PMID:


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Keywords: Selective TRPA1 blockers antagonists Channels Transient Receptor Potential HC030031 TCS5861528 TRPA1

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for TCS 5861528

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