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Submit ReviewTCS 5861528
Description: TRPA1 blocker
Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Purity: ≥98% (HPLC)
Biological Activity for TCS 5861528
TCS 5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.
Compound Libraries for TCS 5861528
TCS 5861528 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for TCS 5861528
| M. Wt | 369.42 |
| Formula | C19H23N5O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 332117-28-9 |
| PubChem ID | 2873523 |
| InChI Key | ZUTUWJYMCADJHD-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS 5861528
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.94 | 100 | |
| ethanol | 3.69 | 10 |
Preparing Stock Solutions for TCS 5861528
The following data is based on the product molecular weight 369.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.71 mL | 13.53 mL | 27.07 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.41 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.71 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for TCS 5861528
References for TCS 5861528
References are publications that support the biological activity of the product.
Wei et al (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111 147 PMID: 19512877
Wei et al (2010) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58 578 PMID: 20004676
Wei et al (2010) Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. 479 253 PMID: 20566388
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Keywords: TCS 5861528, TCS 5861528 supplier, Selective, TRPA1, blockers, antagonists, Channels, Transient, Receptor, Potential, HC030031, TCS5861528, 3938, Tocris Bioscience
1 Citation for TCS 5861528
Citations are publications that use Tocris products. Selected citations for TCS 5861528 include:
Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340
Do you know of a great paper that uses TCS 5861528 from Tocris? Please let us know.
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