TCS 5861528

Pricing Availability   Qty
Cat.No. 3938 - TCS 5861528 | C19H23N5O3 | CAS No. 332117-28-9
Description: TRPA1 blocker
Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity

TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Compound Libraries

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Technical Data

M. Wt 369.42
Formula C19H23N5O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 332117-28-9
PubChem ID 2873523
InChI Key ZUTUWJYMCADJHD-UHFFFAOYSA-N
Smiles O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.94 100
ethanol 3.69 10

Preparing Stock Solutions

The following data is based on the product molecular weight 369.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Wei et al (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111 147 PMID: 19512877

Wei et al (2010) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58 578 PMID: 20004676

Wei et al (2010) Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. 479 253


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Keywords: TCS 5861528, TCS 5861528 supplier, Selective, TRPA1, blockers, antagonists, Channels, Transient, Receptor, Potential, HC030031, TCS5861528, 3938, Tocris Bioscience

1 Citation for TCS 5861528

Citations are publications that use Tocris products. Selected citations for TCS 5861528 include:

Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.