Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 306.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||16.3 mL||81.51 mL||163.02 mL|
|1 mM||3.26 mL||16.3 mL||32.6 mL|
|2 mM||1.63 mL||8.15 mL||16.3 mL|
|10 mM||0.33 mL||1.63 mL||3.26 mL|
References are publications that support the biological activity of the product.
Iversen et al (2000) Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 275 10300 PMID: 10744717
Andersen et al (2002) Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 45 4443 PMID: 12238924
If you know of a relevant reference for TCS 401, please let us know.
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Keywords: TCS 401, TCS 401 supplier, Selective, inhibitors, inhibits, PTP1B, Shp1, Shp2, Protein, Tyrosine, Phosphatases, TCS401, 2754, Tocris Bioscience
1 Citation for TCS 401
Citations are publications that use Tocris products. Selected citations for TCS 401 include:
Du et al (2015) Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. J Neurosci 21 523 PMID: 25999679
Do you know of a great paper that uses TCS 401 from Tocris? Please let us know.
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Literature in this Area
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