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Description: Selective inhibitor of PTP1B
Chemical Name: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
Technical Data for TCS 401
| M. Wt | 306.72 |
| Formula | C10H10N2O5S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 243966-09-8 |
| PubChem ID | 56972185 |
| InChI Key | LQGCAMWQDSYOAY-UHFFFAOYSA-N |
| Smiles | O=C(C(O)=O)NC2=C(C(O)=O)C1=C(S2)CNCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS 401
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 100mM NaOH | 6.13 | 20 |
Preparing Stock Solutions for TCS 401
The following data is based on the product molecular weight 306.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.3 mL | 81.51 mL | 163.02 mL |
| 1 mM | 3.26 mL | 16.3 mL | 32.6 mL |
| 2 mM | 1.63 mL | 8.15 mL | 16.3 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.26 mL |
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Product Datasheets for TCS 401
References for TCS 401
References are publications that support the biological activity of the product.
Iversen et al (2000) Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 275 10300 PMID: 10744717
Andersen et al (2002) Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 45 4443 PMID: 12238924
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Keywords: TCS 401, TCS 401 supplier, Selective, inhibitors, inhibits, PTP1B, Shp1, Shp2, Protein, Tyrosine, Phosphatases, TCS401, 2754, Tocris Bioscience
1 Citation for TCS 401
Citations are publications that use Tocris products. Selected citations for TCS 401 include:
Du et al (2015) Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. J Neurosci 21 523 PMID: 25999679
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