TCS 401

Pricing Availability Delivery Time Qty
Cat.No. 2754 - TCS 401 | C10H10N2O5S.HCl | CAS No. 243966-09-8
Description: Selective inhibitor of PTP1B
Chemical Name: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).

Technical Data

M. Wt 306.72
Formula C10H10N2O5S.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 243966-09-8
PubChem ID 56972185
InChI Key LQGCAMWQDSYOAY-UHFFFAOYSA-N
Smiles O=C(C(O)=O)NC2=C(C(O)=O)C1=C(S2)CNCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.67 25

Preparing Stock Solutions

The following data is based on the product molecular weight 306.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.3 mL 32.6 mL
5 mM 0.65 mL 3.26 mL 6.52 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Iversen et al (2000) Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 275 10300 PMID: 10744717

Andersen et al (2002) Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 45 4443 PMID: 12238924


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Keywords: Selective inhibitors inhibits PTP1B Shp1 Shp2 Protein Tyrosine Phosphatases TCS401 Protein Tyrosine Phosphatases

1 Citation for TCS 401

Citations are publications that use Tocris products. Selected citations for TCS 401 include:

Du et al (2015) Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. J Neurosci 21 523 PMID: 25999679


Do you know of a great paper that uses TCS 401 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
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