TCS 1205

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Cat.No. 3941 - TCS 1205 | C18H15N3O4 | CAS No. 355022-97-8
Description: Subtype-selective GABAA receptor agonist
Chemical Name: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GABAA α2 agonist and GABAA α1 partial agonist in vitro (Ki values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.

Technical Data

M. Wt 337.33
Formula C18H15N3O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 355022-97-8
PubChem ID 10315001
InChI Key VCKKJKQZHHPPDR-LLVKDONJSA-N
Smiles O=C(C(N[C@H](C)C3=CC=CC=C3)=O)C2=CNC1=CC=C([N+]([O-])=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 337.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Primofiore et al (2001) Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 44 2286 PMID: 11428922

Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) κ2 benzodiazepine receptor. J.Med.Chem. 52 3723 PMID: 19469479


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Citations for TCS 1205

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