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TC-S 7006

Cat. No. 5240 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC-S 7006

TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.

Compound Libraries for TC-S 7006

TC-S 7006 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7006

M. Wt 404.83
Formula C21H14ClFN6
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 871307-18-5
PubChem ID 9549300
InChI Key NMEUKWOOQOHUNA-UHFFFAOYSA-N
Smiles FC(C(Cl)=C4)=CC=C4NC1=C2C(C=NC(NCC3=CN=CC=C3)=C2)=NC=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-S 7006

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.48 100

Preparing Stock Solutions for TC-S 7006

The following data is based on the product molecular weight 404.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.35 mL 24.7 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References for TC-S 7006

References are publications that support the biological activity of the product.

Chowdhury et al (2014) Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions. PLoS ONE 9 e92187 PMID: 24642963

Wang et al (2010) Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3. Cell Cycle 9 4542 PMID: 21084834

Gavrin et al (2005) Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg.Med.Chem.Lett. 15 5288 PMID: 16165349

If you know of a relevant reference for TC-S 7006, please let us know.

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Keywords: TC-S 7006, TC-S 7006 supplier, TC-S7006, potent, selective, TPL2, Cot, MAP3K8, inhibits, inhibitors, Other, Kinases, 5240, Tocris Bioscience

1 Citation for TC-S 7006

Citations are publications that use Tocris products. Selected citations for TC-S 7006 include:

Matzaraki et al (2017) An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS One 12 e0180824 PMID: 28727728

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