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Submit ReviewTC-E 5007
Description: Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor
Alternative Names: allo-I1e-isoindoline
Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for TC-E 5007
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.
Technical Data for TC-E 5007
| M. Wt | 268.78 |
| Formula | C14H20N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 91826083 |
| InChI Key | WKUCMHGVDQUBMQ-HTKOBJQYSA-N |
| Smiles | CC[C@@H](C)[C@H](N)C(N1CC(C=CC=C2)=C2C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-E 5007
References for TC-E 5007
References are publications that support the biological activity of the product.
Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988 PMID: 16186403
Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203 PMID: 19439267
Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568 PMID: 17958345
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Keywords: TC-E 5007, TC-E 5007 supplier, TC-E5007, 956039079, 956039_07_9, irreversible, selective, dipeptidyl, peptidases, DPP-8, DPP-9, inhibitors, inhibits, allo-I1e-isoindoline, Other, Proteases, 5204, Tocris Bioscience
Citations for TC-E 5007
Citations are publications that use Tocris products.
Currently there are no citations for TC-E 5007.
Reviews for TC-E 5007
Average Rating: 5 (Based on 2 Reviews.)
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TC-E 5007 inhibits CaMKII phosphorylation in cardiomyocytes.
By
Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: cardiomyocytes
HL-1 cardiomyocytes were treated with TC-E 5007 (1 µM) for 0-60 min and CaMKII phosphorylation was assessed using Western blot.
TC-E 5007 impairs Ca2+ transient relaxation.
By
Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: primary ventricular cardiomyocytes
Representative Ca2+ transient traces of control and a TC-E 5007 (2 µM and 2 h for all)-treated mouse ventricular cardiomyocytes stimulated at 1 Hz frequency. TC-E 5007 increased Ca2+ transient relaxation tau.
