TC-E 5007

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Cat.No. 5204 - TC-E 5007 | C14H20N2O.HCl
Description: Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor
Alternative Names: allo-I1e-isoindoline
Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride
Purity: ≥98% (HPLC)
Reviews (2)
Literature (1)

Biological Activity

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

Technical Data

M. Wt 268.78
Formula C14H20N2O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 91826083
Smiles CC[C@@H](C)[C@H](N)C(N1CC(C=CC=C2)=C2C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 23.23 100
DMSO 23.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 268.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.6 mL 37.21 mL
5 mM 0.74 mL 3.72 mL 7.44 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988 PMID: 16186403

Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203 PMID: 19439267

Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568 PMID: 17958345

If you know of a relevant reference for TC-E 5007, please let us know.

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Keywords: TC-E 5007, TC-E 5007 supplier, TC-E5007, 956039079, 956039_07_9, irreversible, selective, dipeptidyl, peptidases, DPP-8, DPP-9, inhibitors, inhibits, allo-I1e-isoindoline, Other, Proteases, 5204, Tocris Bioscience

Citations for TC-E 5007

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Currently there are no citations for TC-E 5007. Do you know of a great paper that uses TC-E 5007 from Tocris? Please let us know.

Reviews for TC-E 5007

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TC-E 5007 inhibits CaMKII phosphorylation in cardiomyocytes.
By Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: cardiomyocytes

HL-1 cardiomyocytes were treated with TC-E 5007 (1 µM) for 0-60 min and CaMKII phosphorylation was assessed using Western blot.

review image

TC-E 5007 impairs Ca2+ transient relaxation.
By Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: primary ventricular cardiomyocytes

Representative Ca2+ transient traces of control and a TC-E 5007 (2 µM and 2 h for all)-treated mouse ventricular cardiomyocytes stimulated at 1 Hz frequency. TC-E 5007 increased Ca2+ transient relaxation tau.

review image

Literature in this Area

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