TC-E 5007

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Cat.No. 5204 - TC-E 5007 | C14H20N2O.HCl
Description: Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor
Alternative Names: allo-I1e-isoindoline
Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

Technical Data

M. Wt 268.78
Formula C14H20N2O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 91826083
InChI Key WKUCMHGVDQUBMQ-HTKOBJQYSA-N
Smiles CC[C@@H](C)[C@H](N)C(N1CC(C=CC=C2)=C2C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.23 100
DMSO 23.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 268.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.6 mL 37.21 mL
5 mM 0.74 mL 3.72 mL 7.44 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988 PMID: 16186403

Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203 PMID: 19439267

Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568 PMID: 17958345


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Keywords: TC-E 5007, TC-E 5007 supplier, TC-E5007, 956039079, 956039_07_9, irreversible, selective, dipeptidyl, peptidases, DPP-8, DPP-9, inhibitors, inhibits, allo-I1e-isoindoline, Other, Proteases, 5204, Tocris Bioscience

Citations for TC-E 5007

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