TC AC 28

Pricing Availability   Qty
Cat.No. 6105 - TC AC 28 | C23H21N5O3 | CAS No. 1809296-92-1
Description: High affinity BET bromodomain ligand
Chemical Name: 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for TC AC 28

TC AC 28 is a high affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.

Licensing Information

Sold under licence from the University of Dundee.

Technical Data for TC AC 28

M. Wt 415.44
Formula C23H21N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1809296-92-1
PubChem ID 118121364
Smiles COC(CC1N=C(C2=CC(OC)=CC=C2N3C(C)=NN=C13)C4=C5C=CNC5=CC=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC AC 28

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.08 5 with gentle warming

Preparing Stock Solutions for TC AC 28

The following data is based on the product molecular weight 415.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 48.14 mL 240.71 mL 481.42 mL
0.25 mM 9.63 mL 48.14 mL 96.28 mL
0.5 mM 4.81 mL 24.07 mL 48.14 mL
2.5 mM 0.96 mL 4.81 mL 9.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for TC AC 28

References are publications that support the biological activity of the product.

Baud et al (2016) New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition. J.Med.Chem. 59 1492 PMID: 26367539

If you know of a relevant reference for TC AC 28, please let us know.

View Related Products by Target

Keywords: TC AC 28, TC AC 28 supplier, TCAC28, BET, bromodomain, high, affinity, binding, agents, Bromodomains, 6105, Tocris Bioscience

Citations for TC AC 28

Citations are publications that use Tocris products.

Currently there are no citations for TC AC 28. Do you know of a great paper that uses TC AC 28 from Tocris? Please let us know.

Reviews for TC AC 28

There are currently no reviews for this product. Be the first to review TC AC 28 and earn rewards!

Have you used TC AC 28?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cell

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.


Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.