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TC AC 28
High affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.
Sold under licence from the University of Dundee.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.08||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 415.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||48.14 mL||240.71 mL||481.42 mL|
|0.25 mM||9.63 mL||48.14 mL||96.28 mL|
|0.5 mM||4.81 mL||24.07 mL||48.14 mL|
|2.5 mM||0.96 mL||4.81 mL||9.63 mL|
References are publications that support the biological activity of the product.
Baud et al (2016) New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition. J.Med.Chem. 59 1492 PMID: 26367539
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Keywords: TC AC 28, TC AC 28 supplier, TCAC28, BET, bromodomain, high, affinity, binding, agents, Bromodomains, 6105, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
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Epigenetics Research Bulletin
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- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
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