TB 21007

Pricing Availability   Qty
Description: α5-selective GABAA inverse agonist
Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Purity: ≥99% (HPLC)
Citations (2)
Literature (3)

Biological Activity for TB 21007

TB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.

Technical Data for TB 21007

M. Wt 339.5
Formula C15H17NO2S3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 207306-50-1
PubChem ID 6918633
Smiles O=C2C1=C(SCCO)SC(C3=NC=CS3)=C1CC(C)(C)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TB 21007

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.95 100
ethanol 8.49 25

Preparing Stock Solutions for TB 21007

The following data is based on the product molecular weight 339.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for TB 21007

Certificate of Analysis / Product Datasheet
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References for TB 21007

References are publications that support the biological activity of the product.

Chambers et al (2003) Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227 PMID: 12747794

If you know of a relevant reference for TB 21007, please let us know.

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Keywords: TB 21007, TB 21007 supplier, α5, alpha5-selective, GABAA, inverse, agonists, Receptors, TB21007, 2905, Tocris Bioscience

2 Citations for TB 21007

Citations are publications that use Tocris products. Selected citations for TB 21007 include:

Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Clin Invest 64 145 PMID: 22732440

De la Luz-Cuellar et al (2019) Blockade of spinal α5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats. Eur J Pharmacol 858 172443 PMID: 31181208

Do you know of a great paper that uses TB 21007 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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