Taurine

Pricing Availability   Qty
Description: Non-selective, endogenous glycine receptor partial agonist
Chemical Name: 2-Aminoethylsulfonic acid
Datasheet
Citations
Reviews

Biological Activity for Taurine

One of the most abundant free amino acids in the brain. A partial agonist at the inhibitory glycine receptor. May be used in protocols for the generation of retinal pigment epithelial cells from hPSCs. Taurine-fed middle-aged mice have improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, and a longer life span. It reduces cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammation. Taurine supplementation increases health span and life span in worms and health span in non-human primates.

Technical Data for Taurine

M. Wt 125.14
Formula C2H7NO3S
Storage Store at RT
CAS Number 107-35-7
PubChem ID 1123
InChI Key XOAAWQZATWQOTB-UHFFFAOYSA-N
Smiles NCCS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Taurine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 12.51 100

Preparing Stock Solutions for Taurine

The following data is based on the product molecular weight 125.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.99 mL 39.96 mL 79.91 mL
5 mM 1.6 mL 7.99 mL 15.98 mL
10 mM 0.8 mL 4 mL 7.99 mL
50 mM 0.16 mL 0.8 mL 1.6 mL

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Product Datasheets for Taurine

Certificate of Analysis / Product Datasheet
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References for Taurine

References are publications that support the biological activity of the product.

Boldyrev et al (1999) Carnosine and taurine protect rat cerebellar granular cells from free radical damage. Neurosci.Lett. 263 169 PMID: 10213162

Chung et al (1996) Saturable disposition of taurine in the rat cerebrospinal fluid. J.Pharmacol.Exp.Ther. 276 676 PMID: 8632336

Palmi et al (1999) Potentiation of mitochondrial Ca2+ sequestration by taurine. Biochem.Pharmacol. 58 1123 PMID: 10484070

Schmieden and Betz (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol.Pharmacol. 48 919 PMID: 7476923

Surendran et al (2022) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells STAR Protoc. 3 101803 PMID: 36386870

Singh et al (2023) Taurine deficiency as a driver of aging. Science 380 eabn9257 PMID: 37289866


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Keywords: Taurine, Taurine supplier, Non-Selective, endogenous, glycine, receptor, partial, agonists, GlyR, Glycine, Receptors, inhibitory, amino, acid, RPE, retinal, pigment, epithelial, differentiation, Organoids, Retinal, Stem, Cells, 0209, Tocris Bioscience

Citations for Taurine

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