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Biological Activity for Taurine
One of the most abundant free amino acids in the brain. A partial agonist at the inhibitory glycine receptor. May be used in protocols for the generation of retinal pigment epithelial cells from hPSCs. Taurine-fed middle-aged mice have improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, and a longer life span. It reduces cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammation. Taurine supplementation increases health span and life span in worms and health span in non-human primates.
Technical Data for Taurine
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Taurine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Taurine
The following data is based on the product molecular weight 125.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.99 mL||39.96 mL||79.91 mL|
|5 mM||1.6 mL||7.99 mL||15.98 mL|
|10 mM||0.8 mL||4 mL||7.99 mL|
|50 mM||0.16 mL||0.8 mL||1.6 mL|
References for Taurine
References are publications that support the biological activity of the product.
Boldyrev et al (1999) Carnosine and taurine protect rat cerebellar granular cells from free radical damage. Neurosci.Lett. 263 169 PMID: 10213162
Chung et al (1996) Saturable disposition of taurine in the rat cerebrospinal fluid. J.Pharmacol.Exp.Ther. 276 676 PMID: 8632336
Palmi et al (1999) Potentiation of mitochondrial Ca2+ sequestration by taurine. Biochem.Pharmacol. 58 1123 PMID: 10484070
Schmieden and Betz (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol.Pharmacol. 48 919 PMID: 7476923
Surendran et al (2022) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells STAR Protoc. 3 101803 PMID: 36386870
Singh et al (2023) Taurine deficiency as a driver of aging. Science 380 eabn9257 PMID: 37289866
If you know of a relevant reference for Taurine, please let us know.
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Keywords: Taurine, Taurine supplier, Non-Selective, endogenous, glycine, receptor, partial, agonists, GlyR, Glycine, Receptors, inhibitory, amino, acid, RPE, retinal, pigment, epithelial, differentiation, Organoids, Retinal, Stem, Cells, 0209, Tocris Bioscience
Citations for Taurine
Citations are publications that use Tocris products.
Currently there are no citations for Taurine. Do you know of a great paper that uses Taurine from Tocris? Please let us know.
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Literature in this Area
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