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Biological Activity for Targapremir 210
Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.
Technical Data for Targapremir 210
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Targapremir 210
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Targapremir 210
The following data is based on the product molecular weight 592.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.69 mL||8.44 mL||16.87 mL|
|5 mM||0.34 mL||1.69 mL||3.37 mL|
|10 mM||0.17 mL||0.84 mL||1.69 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References for Targapremir 210
References are publications that support the biological activity of the product.
Costales et al (2017) Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. J.Am.Chem.Soc. 139 3446 PMID: 28240549
Childs-Disney et al (2012) Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS.Chem.Biol 7 856 PMID: 22332923
If you know of a relevant reference for Targapremir 210, please let us know.
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Citations for Targapremir 210
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Literature in this Area
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