Tacalcitol

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Cat.No. 4157 - Tacalcitol | C27H44O3 | CAS No. 57333-96-7
Description: Synthetic vitamin D3 (Cat. No. 4156) analog
Chemical Name: (1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Synthetic vitamin D3 (Cat. No. 4156) analog. Promotes normal bone development by regulating calcium. Modulates immunological and inflammatory processes; induces nerve growth factor production in epidermal keratinocytes.

Technical Data

M. Wt 416.64
Formula C27H44O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 57333-96-7
PubChem ID 5283734
InChI Key BJYLYJCXYAMOFT-RSFVBTMBSA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CC[C@@H](O)C(C)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO and in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 416.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fukuoka et al (2001) Tacalcitol, an active vitamin D3, induces nerve growth factor in human epidermal keratinocytes. Skin Pharmacol.Appl.Skin Physiol. 14 226 PMID: 11464105

Rostowska-Nadolska et al (2010) Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblasts. Adv.Med.Sci. 55 86 PMID: 20439185


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View Related Products by Target

Keywords: Tacalcitol VDR receptor vitamin D3 calcitrol analogue bone Vitamin D Receptors

Citations for Tacalcitol

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Literature in this Area

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