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Description: GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
Chemical Name: trans-4-Aminocrotonic acid
Biological Activity for TACA
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.
Technical Data for TACA
| M. Wt | 101.1 |
| Formula | C4H7NO2 |
| Storage | Store at RT |
| CAS Number | 38090-53-8 |
| PubChem ID | 5310987 |
| InChI Key | FMKJUUQOYOHLTF-OWOJBTEDSA-N |
| Smiles | NC/C=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TACA
References for TACA
References are publications that support the biological activity of the product.
Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798
Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147
Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697
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Keywords: TACA, TACA supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA-rho, 0181, Tocris Bioscience
1 Citation for TACA
Citations are publications that use Tocris products. Selected citations for TACA include:
Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One 8 e79126 PMID: 24205371
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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