TACA

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Cat.No. 0181 - TACA | C4H7NO2 | CAS No. 38090-53-8
Description: GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
Chemical Name: trans-4-Aminocrotonic acid
Datasheet
Citations (1)
Reviews
Literature (7)

Biological Activity

The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.

Technical Data

M. Wt 101.1
Formula C4H7NO2
Storage Store at RT
CAS Number 38090-53-8
PubChem ID 5310987
InChI Key FMKJUUQOYOHLTF-OWOJBTEDSA-N
Smiles NC/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 101.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.89 mL 49.46 mL 98.91 mL
5 mM 1.98 mL 9.89 mL 19.78 mL
10 mM 0.99 mL 4.95 mL 9.89 mL
50 mM 0.2 mL 0.99 mL 1.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798

Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147

Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697


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Keywords: TACA, TACA supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA-rho, 0181, Tocris Bioscience

1 Citation for TACA

Citations are publications that use Tocris products. Selected citations for TACA include:

Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One 8 e79126 PMID: 24205371


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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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