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Cat.No. 0181 - TACA | C4H7NO2 | CAS No. 38090-53-8
Description: GABAA agonist. Also GABA-T substrate and GABA uptake inhibitor
Chemical Name: trans-4-Aminocrotonic acid

Biological Activity

The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.

Technical Data

M. Wt 101.1
Formula C4H7NO2
Storage Store at RT
CAS Number 38090-53-8
PubChem ID 5310987
Smiles NC/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 101.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.89 mL 49.46 mL 98.91 mL
5 mM 1.98 mL 9.89 mL 19.78 mL
10 mM 0.99 mL 4.95 mL 9.89 mL
50 mM 0.2 mL 0.99 mL 1.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798

Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147

Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697

If you know of a relevant reference for TACA, please let us know.

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Keywords: TACA, supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA, Receptors, GABAA-rho, Receptors, GABA, Transporters, GABAA, Receptors, Tocris Bioscience

Citations for TACA

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