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Description: GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
Chemical Name: trans-4-Aminocrotonic acid
Biological Activity for TACA
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.
Technical Data for TACA
| M. Wt | 101.1 |
| Formula | C4H7NO2 |
| Storage | Store at RT |
| CAS Number | 38090-53-8 |
| PubChem ID | 5310987 |
| InChI Key | FMKJUUQOYOHLTF-OWOJBTEDSA-N |
| Smiles | NC/C=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TACA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for TACA
The following data is based on the product molecular weight 101.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.89 mL | 49.46 mL | 98.91 mL |
| 5 mM | 1.98 mL | 9.89 mL | 19.78 mL |
| 10 mM | 0.99 mL | 4.95 mL | 9.89 mL |
| 50 mM | 0.2 mL | 0.99 mL | 1.98 mL |
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Product Datasheets for TACA
References for TACA
References are publications that support the biological activity of the product.
Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798
Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147
Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697
If you know of a relevant reference for TACA, please let us know.
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Keywords: TACA, TACA supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA-rho, 0181, Tocris Bioscience
1 Citation for TACA
Citations are publications that use Tocris products. Selected citations for TACA include:
Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One 8 e79126 PMID: 24205371
Do you know of a great paper that uses TACA from Tocris? Please let us know.
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