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Description: GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
Chemical Name: trans-4-Aminocrotonic acid
Citations (1)
Literature (2)

Biological Activity for TACA

The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.

Technical Data for TACA

M. Wt 101.1
Formula C4H7NO2
Storage Store at RT
CAS Number 38090-53-8
PubChem ID 5310987
Smiles NC/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TACA

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for TACA

The following data is based on the product molecular weight 101.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.89 mL 49.46 mL 98.91 mL
5 mM 1.98 mL 9.89 mL 19.78 mL
10 mM 0.99 mL 4.95 mL 9.89 mL
50 mM 0.2 mL 0.99 mL 1.98 mL

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Product Datasheets for TACA

Certificate of Analysis / Product Datasheet
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References for TACA

References are publications that support the biological activity of the product.

Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798

Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147

Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697

If you know of a relevant reference for TACA, please let us know.

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Keywords: TACA, TACA supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA-rho, 0181, Tocris Bioscience

1 Citation for TACA

Citations are publications that use Tocris products. Selected citations for TACA include:

Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One 8 e79126 PMID: 24205371

Do you know of a great paper that uses TACA from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.