T 5601640

Pricing Availability   Qty
Description: Selective LIMK2 inhibitor; antitumor
Alternative Names: T56-LIMKi
Chemical Name: 3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for T 5601640

T 5601640 is a selective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model.

Compound Libraries for T 5601640

T 5601640 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for T 5601640

M. Wt 389.33
Formula C19H14F3N3O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 924473-59-6
PubChem ID 9438169
Smiles O=C(C2=CC=CC(NC(C3=CC(C)=NO3)=O)=C2)NC1=CC(C(F)(F)F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 5601640

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.47 50

Preparing Stock Solutions for T 5601640

The following data is based on the product molecular weight 389.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.14 mL 25.69 mL 51.37 mL
2.5 mM 1.03 mL 5.14 mL 10.27 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
25 mM 0.1 mL 0.51 mL 1.03 mL

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References for T 5601640

References are publications that support the biological activity of the product.

Rak et al (2014) Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model. Oncoscience 1 39 PMID: 25593987

Mashiach-Farkash et al (2012) Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget 3 629 PMID: 22776759

If you know of a relevant reference for T 5601640, please let us know.

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Keywords: T 5601640, T 5601640 supplier, T5601640, Selective, LIMK2, inhibitors, inhibits, lim, kinases, antitumour, antitumor, cofilin, T56-LIMKi, LIMK, 5269, Tocris Bioscience

Citations for T 5601640

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