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Submit ReviewT 5601640
Description: Selective LIMK2 inhibitor; antitumor
Alternative Names: T56-LIMKi
Chemical Name: 3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
Purity: ≥99% (HPLC)
Biological Activity for T 5601640
T 5601640 is a selective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model.
Compound Libraries for T 5601640
T 5601640 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for T 5601640
| M. Wt | 389.33 |
| Formula | C19H14F3N3O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 924473-59-6 |
| PubChem ID | 9438169 |
| InChI Key | XVOKFRPKSAWELK-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=CC(NC(C3=CC(C)=NO3)=O)=C2)NC1=CC(C(F)(F)F)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for T 5601640
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.47 | 50 |
Preparing Stock Solutions for T 5601640
The following data is based on the product molecular weight 389.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.14 mL | 25.69 mL | 51.37 mL |
| 2.5 mM | 1.03 mL | 5.14 mL | 10.27 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 25 mM | 0.1 mL | 0.51 mL | 1.03 mL |
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Product Datasheets for T 5601640
References for T 5601640
References are publications that support the biological activity of the product.
Rak et al (2014) Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model. Oncoscience 1 39 PMID: 25593987
Mashiach-Farkash et al (2012) Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget 3 629 PMID: 22776759
If you know of a relevant reference for T 5601640, please let us know.
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Keywords: T 5601640, T 5601640 supplier, T5601640, Selective, LIMK2, inhibitors, inhibits, lim, kinases, antitumour, antitumor, cofilin, T56-LIMKi, LIMK, 5269, Tocris Bioscience
Citations for T 5601640
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Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.