Suplatast tosylate

Discontinued Product

Suplatast tosylate (Cat. No. 3543) has been withdrawn from sale for commercial reasons.
Cat.No. 3543 - Suplatast tosylate | C16H26NO4S.C7H7O3S | CAS No. 94055-76-2
Description: Th2 cytokine synthesis inhibitor; antiasthmatic
Alternative Names: IPD 1151T
Chemical Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium 4-methylbenzenesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Suplatast tosylate

Suplatast tosylate is a th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.

Technical Data for Suplatast tosylate

M. Wt 499.64
Formula C16H26NO4S.C7H7O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94055-76-2
PubChem ID 71773
InChI Key RYVJQEZJUFRANT-UHFFFAOYSA-N
Smiles O=C(CC[S+](C)C)NC1=CC=C(OCC(O)COCC)C=C1.CC2=CC=C(S(=O)([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Suplatast tosylate

References for Suplatast tosylate

References are publications that support the biological activity of the product.

Kurokawa et al (2001) Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo. Mediators Inflamm. 10 333 PMID: 11817674

Hsu et al (2007) The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells. Transpl.Immunol. 18 108 PMID: 18005853

Furonaka et al (2009) Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice. J.Pharmacol.Exp.Ther. 328 55 PMID: 18832650

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Keywords: Suplatast tosylate, Suplatast tosylate supplier, Th2, cytokine, synthesis, inhibitors, inhibits, antiasthmatic, TNF-α, TNF-alpha, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, IPD1151T, IPD, 1151T, 3543, Tocris Bioscience

Citations for Suplatast tosylate

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Currently there are no citations for Suplatast tosylate.

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