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Suplatast tosylate

Cat. No. 3543 Submit a Review Datasheet / COA / SDS
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Cat.No. 3543 - Suplatast tosylate | C16H26NO4S.C7H7O3S | CAS No. 94055-76-2
Description: Th2 cytokine synthesis inhibitor; antiasthmatic
Alternative Names: IPD 1151T
Chemical Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium 4-methylbenzenesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.

Technical Data

M. Wt 499.64
Formula C16H26NO4S.C7H7O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94055-76-2
PubChem ID 71773
InChI Key RYVJQEZJUFRANT-UHFFFAOYSA-N
Smiles O=C(CC[S+](C)C)NC1=CC=C(OCC(O)COCC)C=C1.CC2=CC=C(S(=O)([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 49.96 100
DMSO 49.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 499.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.01 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References

References are publications that support the biological activity of the product.

Kurokawa et al (2001) Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo. Mediators Inflamm. 10 333 PMID: 11817674

Hsu et al (2007) The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells. Transpl.Immunol. 18 108 PMID: 18005853

Furonaka et al (2009) Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice. J.Pharmacol.Exp.Ther. 328 55 PMID: 18832650

If you know of a relevant reference for Suplatast tosylate, please let us know.

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