Suplatast tosylate

Pricing Availability Delivery Time Qty
Cat.No. 3543 - Suplatast tosylate | C16H26NO4S.C7H7O3S | CAS No. 94055-76-2
Description: Th2 cytokine synthesis inhibitor; antiasthmatic
Alternative Names: IPD 1151T
Chemical Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium 4-methylbenzenesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.

Technical Data

M. Wt 499.64
Formula C16H26NO4S.C7H7O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94055-76-2
PubChem ID 71773
InChI Key RYVJQEZJUFRANT-UHFFFAOYSA-N
Smiles O=C(CC[S+](C)C)NC1=CC=C(OCC(O)COCC)C=C1.CC2=CC=C(S(=O)([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.96 100
ethanol 49.96 100
water 49.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 499.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.01 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kurokawa et al (2001) Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo. Mediators Inflamm. 10 333 PMID: 11817674

Hsu et al (2007) The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells. Transpl.Immunol. 18 108 PMID: 18005853

Furonaka et al (2009) Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice. J.Pharmacol.Exp.Ther. 328 55 PMID: 18832650


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Keywords: Th2 cytokine synthesis inhibitors inhibits antiasthmatic TNF-α TNF-alpha Interleukins Tumor Necrosis Factor-α Factor-alpha Cytokines Cytokine NF-κB NF-kappaB Signaling Signalling IPD1151T IPD 1151T Cytokines

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