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Cat.No. 6575 - StRIP16 | N-Ac-Asp-Asn-Glu-[(S)-2-(4-pentenyl)alanine]-Gln-Trp-Phe-[(S)-2-(4-pentenyl)alanine]-Tyr-His-Leu-[(S)-2-(4-pentenyl)alanine]-Phe-Phe-Asn-[(S)-2-(4-pentenyl)alanine]-Val-NH2 (double bond covalent bridge: X-4-X-8 and X-12-X-16)
Description: Rab8a GTPase-binding stapled peptide
Literature (1)

Biological Activity

Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.

Technical Data

M. Wt 2300.61
Formula C116H154N24O26

(Modifications: Asp-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-4 and X-8 stapled together with a double bond, X-12 and X-16 stapled together with a double bond, Val-17 = C-terminal amide)

Storage Store at -20°C
Smiles CC(C[C@@H](C(N[C@]1(CCC/C=C/CCC[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)CC(N)=O)=O)(C(N[C@H](C(N)=O)C(C)C)=O)C)C)=O)NC([C@@H](NC([C@@H](NC([C@@]4(CCC/C=C/CCC[C@](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)NC(C)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N4)=O)CC5=CC=CC=C5)=O)CC6=CNC7=CC=CC=C67)=O)CCC(N)=O)=O)C)C)=O)CC8=CC=C(C=C8)O)=O)CC9=CN=CN9)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 40% acetonitrile / water


References are publications that support the biological activity of the product.

Cromm et al (2016) Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase. ACS Chem.Biol. 11 2375 PMID: 27336832

If you know of a relevant reference for StRIP16, please let us know.

Keywords: StRIP16, StRIP16 supplier, RAb8a, binding, stapled, peptides, GTPase, binds, cell-permeable, Other, Small, Monomeric, GTPases, Stapled, Peptides, 6575, Tocris Bioscience

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